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Nanomaterials 2019, 9(4), 532; https://doi.org/10.3390/nano9040532

Electrospinning Nanofibers for Therapeutics Delivery

1
Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 27469, Korea
2
Department of Green Bio Engineering, Korea National University of Transportation, Chungju 27469, Korea
3
Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science & Technology (INST), Hanyang University, Seoul 04763, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 20 February 2019 / Revised: 21 March 2019 / Accepted: 22 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Electrospun Nanofibers for Biomedical Applications)
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Abstract

The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications. View Full-Text
Keywords: electrospinning; nanofibers; fabrication; therapeutics; biomedical applications electrospinning; nanofibers; fabrication; therapeutics; biomedical applications
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Shahriar, S.M.S.; Mondal, J.; Hasan, M.N.; Revuri, V.; Lee, D.Y.; Lee, Y.-K. Electrospinning Nanofibers for Therapeutics Delivery. Nanomaterials 2019, 9, 532.

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