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Nanomaterials 2019, 9(3), 410; https://doi.org/10.3390/nano9030410

PEGylated Magnetic Nano-Assemblies as Contrast Agents for Effective T2-Weighted MR Imaging

1
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Korea
2
BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea
3
Department of Nanobiotechnology, KRIBB School of Biotechnology, University of Science & Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon 34113, Korea
4
Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Korea
5
Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 03722, Korea
6
YUHS-KRIBB Medical Convergence Research Institute, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
Received: 7 February 2019 / Revised: 4 March 2019 / Accepted: 6 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue Nanoscience and Health: Tiny Technology Raises Big Questions)
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Abstract

We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65–70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site. View Full-Text
Keywords: Magnetic resonance image; PEGylated; Poly(ethylene glycol)-poly(lactic acid); contrast agent Magnetic resonance image; PEGylated; Poly(ethylene glycol)-poly(lactic acid); contrast agent
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kang, B.; Lim, J.; Son, H.-Y.; Choi, Y.; Kang, T.; Jung, J.; Huh, Y.-M.; Haam, S.; Lim, E.-K. PEGylated Magnetic Nano-Assemblies as Contrast Agents for Effective T2-Weighted MR Imaging. Nanomaterials 2019, 9, 410.

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