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DNA-Based Assembly of Quantum Dots into Dimers and Helices

*,† and
Faculty of Physics and Center for Nanoscience (CeNS), Ludwig-Maximilians-Universität München (LMU), D-80539 Munich, Germany
Author to whom correspondence should be addressed.
Current address: Max-Planck-Institute for Intelligent Systems, D-70569 Stuttgart, Germany.
Nanomaterials 2019, 9(3), 339;
Received: 30 January 2019 / Revised: 20 February 2019 / Accepted: 21 February 2019 / Published: 2 March 2019
(This article belongs to the Special Issue Applications of Quantum Dots)
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Owing to their unique optical properties, colloidal quantum dots (QDs) have attracted much attention as versatile fluorescent markers with broad biological and physical applications. On the other hand, DNA-based assembly has proven to be a powerful bottom-up approach to create designer nanoscale objects and to use these objects for the site-directed arrangement of guest components. To achieve good colloidal stability and accurate positioning of QDs on DNA templates, robust QD surface functionalization is crucial. Here, we present a simple and reliable conjugation method for the direct attachment of DNA molecules to QDs. Phosphorothiolated regions of chimera oligonucleotides are attached and incorporated into a ZnS layer freshly growing in situ on QDs that were rendered water soluble with hydrophilic ligands in a prior step. The reaction can be completed in a 2 mL plastic tube without any special equipment. The utility of these DNA-labeled QDs is demonstrated via prototypical assemblies such as QDs dimers with various spacings and chiral helical architectures. View Full-Text
Keywords: quantum dots; DNA–QDs conjugation; DNA nanotechnology quantum dots; DNA–QDs conjugation; DNA nanotechnology

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, T.; Liedl, T. DNA-Based Assembly of Quantum Dots into Dimers and Helices. Nanomaterials 2019, 9, 339.

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