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Nanomaterials 2019, 9(2), 253; https://doi.org/10.3390/nano9020253

Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release

1
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
2
Shaanxi Province Key Lab of Paper Technology and Specialty Paper, Shaanxi University of Science and Technology, Xi’an 710021, China
3
College of Leather Chemical and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
*
Authors to whom correspondence should be addressed.
Received: 3 January 2019 / Revised: 28 January 2019 / Accepted: 9 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Nanocellulose and Nanochitin: Characterization and Applicaitions)
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Abstract

In this work, a novel nanocomposite hydrogel based on cellulose nanocrystal (CNC) and chitosan (CS) was fabricated and applied as a carrier for the controlled delivery of theophylline. CNC was firstly periodate-oxidized to obtain dialdehyde nanocellulose (DACNC). Then, chitosan was crosslinked using DACNC as both the matrix and crosslinker in different weight ratios, to fabricate CNC/CS composites. The prepared composites were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction pattern (XRD), scanning electron microscopy (SEM), zeta potential measurement and swelling ratio tests. FT-IR results confirmed the successful reaction between the free amino groups on chitosan and the aldehyde groups on DACNC. With the increase of chitosan percentage in the hydrogel, the isoelectric point was shifted towards an alkaline pH, which was probably caused by the higher content of free amino groups. The swelling ratio of the composite also increased, which may have been due to the decrease of crosslinking density. Because the swelling ratio of the drug-loaded hydrogels differed under varied pH values, the cumulative drug release percentage of the composite hydrogel was achieved to approximately 85% and 23% in the gastric (pH 1.5) and intestinal (pH 7.4) fluids, respectively. Therefore, CNC/CS hydrogel has application potential as a theophylline carrier. View Full-Text
Keywords: cellulose nanocrystal; periodate oxidation; chitosan; hydrogel; drug delivery cellulose nanocrystal; periodate oxidation; chitosan; hydrogel; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xu, Q.; Ji, Y.; Sun, Q.; Fu, Y.; Xu, Y.; Jin, L. Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release. Nanomaterials 2019, 9, 253.

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