Next Article in Journal
Dynamically Tunable Resonant Strength in Electromagnetically Induced Transparency (EIT) Analogue by Hybrid Metal-Graphene Metamaterials
Previous Article in Journal
Fully Printed Zinc Oxide Electrolyte-Gated Transistors on Paper
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Nanomaterials 2019, 9(2), 170; https://doi.org/10.3390/nano9020170

T1-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule

The Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China
*
Authors to whom correspondence should be addressed.
Those authors contributed equally to this work.
Received: 7 January 2019 / Revised: 24 January 2019 / Accepted: 26 January 2019 / Published: 30 January 2019
Full-Text   |   PDF [2667 KB, uploaded 30 January 2019]   |  

Abstract

To optimize the iron oxide nanoparticles as T1-weight contrast for in vivo magnetic resonance imaging (MRI), numbers of macromolecule ligands have been explored with considerable effort. However, reports refer to the comparison of the T1-weight contrast performances of iron oxide nanoparticles modified with natural and artificial macromolecule ligands are still limited. In this work, we used a typical natural protein macromolecule (bovine serum albumin, BSA) and an artificial macromolecule (poly(acrylic acid)-poly(methacrylic acid), PMAA-PTTM) as surface ligands to fabricate Fe3O4-BSA and Fe3O4-PMAA-PTTM nanoparticles with similar size and magnetization by the coprecipitation method and compared their MRI performances. In vitro and in vivo experiments revealed that Fe3O4-BSA with lower cytotoxicity exhibited higher r2/r1 ratio in solution and darkening contrast enhancement for liver and kidney sites of mice under T1-weight imaging, while Fe3O4-PMAA-PTTM displayed much lower r2/r1 ratio in solution and brighter contrast enhancement for liver and kidney sites. These remarkably different MRI behaviors demonstrated that the surface ligands play an important role for optimizing the MRI performance of Fe3O4 nanoparticles. We expect these results may facilitate the design of macromolecule ligands for developing an iron oxide–based T1-weight contrast agent. View Full-Text
Keywords: magnetic resonance imaging; T1-weight contrasts; magnetic nanoparticles; iron oxide; macromolecule ligands magnetic resonance imaging; T1-weight contrasts; magnetic nanoparticles; iron oxide; macromolecule ligands
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tao, C.; Zheng, Q.; An, L.; He, M.; Lin, J.; Tian, Q.; Yang, S. T1-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule. Nanomaterials 2019, 9, 170.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top