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Open AccessArticle

An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries

by 1,2,3, 1,2,3, 1,2,3, 1,3,† and 1,2,3,*
1
MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington 6140, New Zealand
2
Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand
3
School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
*
Author to whom correspondence should be addressed.
Current address: School of Mathematical and Physical Sciences, University of Newcastle, Newcastle 2304, Australia.
Nanomaterials 2019, 9(2), 135; https://doi.org/10.3390/nano9020135
Received: 29 November 2018 / Revised: 15 January 2019 / Accepted: 18 January 2019 / Published: 22 January 2019
Indium phosphide quantum dots (QDs) passivated with zinc sulphide in a core/shell architecture (InP/ZnS) with different surface chemistries were introduced to RAW 264.7 murine “macrophage-like” cells to understand their potential toxicities. The InP/ZnS quantum dots were conjugated with an oligonucleotide, a carboxylic acid, or an amino-polyethylene glycol ligand, and cell viability and cell proliferation were investigated via a metabolic assay. Membrane integrity was measured through the production of lactate dehydrogenase. Fluorescence microscopy showed cellular uptake. All quantum dots exhibited cytotoxic behaviour less than that observed from cadmium- or lead-based quantum dots; however, this behaviour was sensitive to the ligands used. In particular, the amino-polyethylene glycol conjugated quantum dots proved to possess the highest cytotoxicity examined here. This provides quantitative evidence that aqueous InP/ZnS quantum dots can offer a safer alternative for bioimaging or in therapeutic applications. View Full-Text
Keywords: quantum yields; aptamer; photoluminescence; cytotoxicity; quantum dots; bioimaging quantum yields; aptamer; photoluminescence; cytotoxicity; quantum dots; bioimaging
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MDPI and ACS Style

Ayupova, D.; Dobhal, G.; Laufersky, G.; Nann, T.; Goreham, R.V. An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries. Nanomaterials 2019, 9, 135. https://doi.org/10.3390/nano9020135

AMA Style

Ayupova D, Dobhal G, Laufersky G, Nann T, Goreham RV. An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries. Nanomaterials. 2019; 9(2):135. https://doi.org/10.3390/nano9020135

Chicago/Turabian Style

Ayupova, Deanna; Dobhal, Garima; Laufersky, Geoffry; Nann, Thomas; Goreham, Renee V. 2019. "An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries" Nanomaterials 9, no. 2: 135. https://doi.org/10.3390/nano9020135

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