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Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

1
National University of Science and Technology “MISIS”, Leninsky prospect 4, 119049 Moscow, Russia
2
Laboratory of New Materials Simulation, FSBI Technological Institute for Superhard and Novel Carbon Materials, 7a Tsentralnaya street, Troitsk, 108840 Moscow, Russia
3
CEITEC-Central European Institute of Technology, Brno University of Technology, Technická 3058/10, 61600 Brno, Czech Republic
4
Institute of Physical Engineering, Brno University of Technology, Technicka 2896/2, 61669 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1658; https://doi.org/10.3390/nano9121658
Received: 21 October 2019 / Revised: 13 November 2019 / Accepted: 19 November 2019 / Published: 21 November 2019
A new low-pressure plasma-based approach to activate the surface of BN nanoparticles (BNNPs) in order to facilitate the attachment of folate acid (FA) molecules for cancer-specific therapy is described. Plasma treatment of BNNPs (BNNPsPT) was performed in a radiofrequency plasma reactor using ethylene and carbon dioxide monomers. The carboxyl groups deposited on the surface of BNNPsPT were activated by N,N’-dicyclohexylcarbodiimide (DCC) and participated in the condensation reaction with ethylene diamine (EDA) to form a thin amino-containing layer (EDA-BNNPPT). Then, the DCC-activated FA was covalently bonded with BNNPsPT by a chemical reaction between amino groups of EDA-BNNPsPT and carboxyl groups of FA. Density functional theory calculations showed that the pre-activation of FA by DCC is required for grafting of the FA to the EDA-BNNPsPT. It was also demonstrated that after FA immobilization, the electronic characteristics of the pteridine ring remain unchanged, indicating that the targeting properties of the FA/EDA-BNNPsPT nanohybrids are preserved. View Full-Text
Keywords: BN nanoparticles; chemical vapor deposition; plasma surface polymerization; folic acid conjugates; drug delivery nanocarriers; density functional theory BN nanoparticles; chemical vapor deposition; plasma surface polymerization; folic acid conjugates; drug delivery nanocarriers; density functional theory
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Permyakova, E.S.; Antipina, L.Y.; Kiryukhantsev-Korneev, P.V.; Kovalskii, A.M.; Polčak, J.; Manakhov, A.; Gudz, K.Y.; Sorokin, P.B.; Shtansky, D.V. Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study. Nanomaterials 2019, 9, 1658.

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