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Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities

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Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi Arabia
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Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi Arabia
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Department of Physics, College of Science, Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi Arabia
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Department of Stem Cell Biology, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Post Box No. 1982, Dammam 31441, Saudi Arabia
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Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi Arabia
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Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1635; https://doi.org/10.3390/nano9111635
Received: 25 October 2019 / Revised: 11 November 2019 / Accepted: 12 November 2019 / Published: 18 November 2019
(This article belongs to the Special Issue Functional Nanomagnetics and Magneto-Optical Nanomaterials)
Manganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn0.5Zn0.5SmxEuxFe1.8−2xO4 (0.01 ≤ x ≤ 0.05) nanoparticles (NPs) by using the hydrothermal approach. The structure and surface morphology of the products were determined by X-ray powder diffraction (XRD), transmission electron and scanning electron microcopies (TEM and SEM), along with energy dispersive X-ray spectroscopy (EDX). We evaluated the impact of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 NPs on both human embryonic stem cells (HEK-293) (normal cells) and human colon carcinoma cells (HCT-116) (cancerous cells). We found that post-48 h of treatment of all products showed a significant decline in the cancer cell population as revealed by microscopically and the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium (MTT) assay. The inhibitory concentration (IC50) values of the products ranged between 0.75 and 2.25 µg/mL. When tested on normal and healthy cells (HEK-293), we found that the treatment of products did not produce any effects on the normal cells, which suggests that all products selectively targeted the cancerous cells. The anti-bacterial properties of the samples were also evaluated by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays, which showed that products also inhibited the bacterial growth. View Full-Text
Keywords: spinel ferrites; cytotoxicity; antibacterial activity; hydrothermal synthesis spinel ferrites; cytotoxicity; antibacterial activity; hydrothermal synthesis
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Akhtar, S.; Rehman, S.; Almessiere, M.A.; Khan, F.A.; Slimani, Y.; Baykal, A. Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities. Nanomaterials 2019, 9, 1635.

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