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Open AccessArticle

In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

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Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica-Voda Alley, 700487 Iasi, Romania
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Laboratory of Antimicrobial Chemotherapy, “Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, 8 Sadoveanu Alley, 700489 Iasi, Romania
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Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1565; https://doi.org/10.3390/nano9111565
Received: 18 September 2019 / Revised: 21 October 2019 / Accepted: 1 November 2019 / Published: 4 November 2019
Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications. View Full-Text
Keywords: core-shell magnetic nanoparticles; antioxidant activity; free radical scavengers; cerium oxide nanoparticles core-shell magnetic nanoparticles; antioxidant activity; free radical scavengers; cerium oxide nanoparticles
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Turin-Moleavin, I.-A.; Fifere, A.; Lungoci, A.-L.; Rosca, I.; Coroaba, A.; Peptanariu, D.; Nastasa, V.; Pasca, S.-A.; Bostanaru, A.-C.; Mares, M.; Pinteala, M. In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates. Nanomaterials 2019, 9, 1565.

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