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Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects

by Baoqing Pei 1,2, Wei Wang 1,2, Nicholas Dunne 3,* and Xiaoming Li 1,2,*
1
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
2
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China
3
Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Stokes Building, Collins Avenue, Dublin 9, Ireland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(10), 1501; https://doi.org/10.3390/nano9101501
Received: 18 September 2019 / Revised: 10 October 2019 / Accepted: 17 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Bone Regeneration)
With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure and properties under physiological conditions. The characteristic properties of carbon nanotubes (CNTs) make them an ideal candidate for developing innovative biomimetic materials in the bone biomedical field. Indeed, CNT-based materials and their composites possess the promising potential to revolutionize the design and integration of bone scaffolds or implants, as well as drug therapeutic systems. This review summarizes the unique physicochemical and biomedical properties of CNTs as structural biomaterials and reinforcing agents for bone repair as well as provides coverage of recent concerns and advancements in CNT-based materials and composites for bone tissue regeneration and engineering. Moreover, this review discusses the research progress in the design and development of novel CNT-based delivery systems in the field of bone tissue engineering. View Full-Text
Keywords: carbon nanotubes; bone regeneration; tissue engineering; scaffolds; drug system carbon nanotubes; bone regeneration; tissue engineering; scaffolds; drug system
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Pei, B.; Wang, W.; Dunne, N.; Li, X. Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects. Nanomaterials 2019, 9, 1501.

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