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Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites

Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary
Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1., H-6720 Szeged, Hungary
Reaction Kinetics and Surface Chemistry Research Group, Hungarian Academy of Sciences-University of Szeged, Rerrich Béla tér 1, H-6720 Szeged, Hungary
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(10), 1406;
Received: 17 September 2019 / Accepted: 28 September 2019 / Published: 2 October 2019
(This article belongs to the Special Issue Titanate Nanostructures)
Recently, there has been an increasing interest in the application of nanotubular structures for drug delivery. There are several promising results with carbon nanotubes; however, in light of some toxicity issues, the search for alternative materials has come into focus. The objective of the present study was to investigate the influence of the applied solvent on the composite formation of titanate nanotubes (TNTs) with various drugs in order to improve their pharmacokinetics, such as solubility, stability, and bioavailability. Composites were formed by the dissolution of atenolol (ATN) and hydrochlorothiazide (HCT) in ethanol, methanol, 0.01 M hydrochloric acid or in ethanol, 1M sodium hydroxide, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), respectively, and then they were mixed with a suspension of TNTs under sonication for 30 min and vacuum-dried for 24 h. The structural properties of composites were characterized by SEM, TEM, FT-IR, differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, and optical contact angle (OCA) measurements. Drug release was determined from the fast disintegrating tablets using a dissolution tester coupled with a UV–Vis spectrometer. The results revealed that not only the good solubility of the drug in the applied solvent, but also the high volatility of the solvent, is necessary for an optimal composite-formation process. View Full-Text
Keywords: atenolol; hydrochlorothiazide; titanate nanotubes; composite formation; solvent selection atenolol; hydrochlorothiazide; titanate nanotubes; composite formation; solvent selection
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Ranjous, Y.; Regdon, G., Jr.; Pintye-Hódi, K.; Varga, T.; Szenti, I.; Kónya, Z.; Sovány, T. Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites. Nanomaterials 2019, 9, 1406.

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