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Nanomaterials 2018, 8(8), 629; https://doi.org/10.3390/nano8080629

Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine

1
College of Chemistry and Materials Science, Fujian Key Laboratory of Polymer Materials, Fuzhou, Fujian 350007, China
2
Center of Engineering Technology Research for Microalgae Germplasm Improvement of Fujian, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, Fujian 350117, China
3
Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, Fujian 350117, China
4
Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, Fujian 350117, China
*
Author to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 7 August 2018 / Accepted: 16 August 2018 / Published: 20 August 2018
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Abstract

Herein we utilized coordination interactions to prepare a novel core-shell plasmonic nanosensor for the detection of glucose. Specifically, Au nanoparticles (NPs) were strongly linked with Ag+ ions to form a sacrificial Ag shell by using 4-aminothiophenol (4-PATP) as a mediator, which served as an internal standard to decrease the influence of the surrounding on the detection. The resultant Au-PATP-Ag core-shell systems were characterized by UV-vis spectroscopy, transmission electron microscopy, and surface-enhanced Raman scattering (SERS) techniques. Experiments performed with R6G (rhodamine 6G) and CV (crystal violet) as Raman reporters demonstrated that the Au@Ag nanostructure amplified SERS signals obviously. Subsequently, the Au@Ag NPs were decorated with 4-mercaptophenylboronic acid (4-MPBA) to specifically recognize glucose by esterification, and a detection limit as low as 10−4 M was achieved. Notably, an enhanced linearity for the quantitative detection of glucose (R2 = 0.995) was obtained after the normalization of the spectral peaks using 4-PATP as the internal standard. Finally, the practical applicability of the developed sensing platform was demonstrated by the detection of glucose in urine with acceptable specificity. View Full-Text
Keywords: Au@Ag core-shell nanostructure; 4-PATP; glucose; internal standard; surface-enhanced Raman scattering Au@Ag core-shell nanostructure; 4-PATP; glucose; internal standard; surface-enhanced Raman scattering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lu, Y.; Zhou, T.; You, R.; Wu, Y.; Shen, H.; Feng, S.; Su, J. Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine. Nanomaterials 2018, 8, 629.

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