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Nanomaterials 2018, 8(8), 605;

Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications

Laboratory of Cytogenetics, West Pomeranian University of Technology, Szczecin, Klemensa Janickiego 29, 71-270 Szczecin, Poland
Nanomaterials Physicochemistry Department, West Pomeranian University of Technology, Szczecin, Piastow Avenue 45, 70-311 Szczecin, Poland
Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111 Szczecin, Poland
Authors to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 3 August 2018 / Accepted: 4 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Boron Nitride Nanostructures)
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Hexagonal boron nitride is often referred to as white graphene. This is a 2D layered material, with a structure similar to graphene. It has gained many applications in cosmetics, dental cements, ceramics etc. Hexagonal boron nitride is also used in medicine, as a drug carrier similar as graphene or graphene oxide. Here we report that this material can be exfoliated in two steps: chemical treatment (via modified Hummers method) followed by the sonication treatment. Afterwards, the surface of the obtained material can be efficiently functionalized with gold nanoparticles. The mitochondrial activity was not affected in L929 and MCF-7 cell line cultures during 24-h incubation, whereas longer incubation (for 48, and 72 h) with this nanocomposite affected the cellular metabolism. Lysosome functionality, analyzed using the NR uptake assay, was also reduced in both cell lines. Interestingly, the rate of MCF-7 cell proliferation was reduced when exposed to h-BN loaded with gold nanoparticles. It is believed that h-BN nanocomposite with gold nanoparticles is an attractive material for cancer drug delivery and photodynamic therapy in cancer killing. View Full-Text
Keywords: boron nitride; nanocomposite; functionalization; gold nanoparticles; cytobiocompatibility boron nitride; nanocomposite; functionalization; gold nanoparticles; cytobiocompatibility

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Jedrzejczak-Silicka, M.; Trukawka, M.; Dudziak, M.; Piotrowska, K.; Mijowska, E. Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications. Nanomaterials 2018, 8, 605.

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