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Nanomaterials 2018, 8(7), 457; https://doi.org/10.3390/nano8070457

Protein-Based Fiber Materials in Medicine: A Review

1
Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028, USA
2
Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA
3
Department of Mechanical Engineering, Rowan University, Glassboro, NJ 08028, USA
4
Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 7 May 2018 / Revised: 11 June 2018 / Accepted: 20 June 2018 / Published: 22 June 2018
(This article belongs to the Special Issue Tissue Engineering and Regenerative Nanomedicine)
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Abstract

Fibrous materials have garnered much interest in the field of biomedical engineering due to their high surface-area-to-volume ratio, porosity, and tunability. Specifically, in the field of tissue engineering, fiber meshes have been used to create biomimetic nanostructures that allow for cell attachment, migration, and proliferation, to promote tissue regeneration and wound healing, as well as controllable drug delivery. In addition to the properties of conventional, synthetic polymer fibers, fibers made from natural polymers, such as proteins, can exhibit enhanced biocompatibility, bioactivity, and biodegradability. Of these proteins, keratin, collagen, silk, elastin, zein, and soy are some the most common used in fiber fabrication. The specific capabilities of these materials have been shown to vary based on their physical properties, as well as their fabrication method. To date, such fabrication methods include electrospinning, wet/dry jet spinning, dry spinning, centrifugal spinning, solution blowing, self-assembly, phase separation, and drawing. This review serves to provide a basic knowledge of these commonly utilized proteins and methods, as well as the fabricated fibers’ applications in biomedical research. View Full-Text
Keywords: protein; nanofibers; biomaterials fabrication; medicine; tissue engineering; wound healing; drug delivery protein; nanofibers; biomaterials fabrication; medicine; tissue engineering; wound healing; drug delivery
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DeFrates, K.G.; Moore, R.; Borgesi, J.; Lin, G.; Mulderig, T.; Beachley, V.; Hu, X. Protein-Based Fiber Materials in Medicine: A Review. Nanomaterials 2018, 8, 457.

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