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Nanomaterials 2018, 8(6), 410; https://doi.org/10.3390/nano8060410

Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration

1
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA
2
Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, 2730 SW Moody Ave, Portland, OR 97201, USA
3
Department of Radiation Medicine, School of Medicine, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 18 May 2018 / Revised: 3 June 2018 / Accepted: 4 June 2018 / Published: 7 June 2018
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Abstract

Platinum nanoparticles (PtNPs) have shown promise as diagnostic and therapeutic agents due to their unique physiochemical properties. However, critical parameters, such as toxicity and accumulation at both desired and other tissues, remain a significant concern in the clinical translation of these nanomaterials. Here, we examine the cytotoxicity, biodistribution, and effect on clearance organ function of an intravenously administered polyethylene glycol (PEG) -ylated PtNP construct. We synthesized hydrophobic PtNPs and assembled them into aqueous micelles with the lipid-polymer conjugate 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG (PtNP: DSPE-PEG, ~70 nm). This construct was well tolerated in mice receiving up to 15 mg platinum per kg body weight with no observed loss in weight, plasma chemistry within normal healthy ranges, and normal histopathology of organs after three weeks. Platinum quantification studies (inductively-coupled plasma mass spectroscopy (ICP-MS)) were also performed to assess biodistribution of PtNPs. The findings of this study are consistent with the in vivo accumulation of metal nanomaterials and further highlight the need to address clearance when designing nanomaterials for medical applications. View Full-Text
Keywords: platinum; nanoparticle; noble metal nanoparticles; in vivo toxicity; bioaccumulation platinum; nanoparticle; noble metal nanoparticles; in vivo toxicity; bioaccumulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Brown, A.L.; Kai, M.P.; DuRoss, A.N.; Sahay, G.; Sun, C. Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration. Nanomaterials 2018, 8, 410.

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