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Nanomaterials 2018, 8(5), 300; https://doi.org/10.3390/nano8050300

Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe

1
Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 41566, Korea
2
Department of Bio-fibers and materials Science, Kyungpook National University, Daegu 41566, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 5 April 2018 / Revised: 27 April 2018 / Accepted: 3 May 2018 / Published: 5 May 2018
(This article belongs to the Special Issue Organic-Inorganic Hybrid Nanomaterials)
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Abstract

The combination of magnetic and plasmonic properties using iron oxide/gold nanocomposite particles is crucial for the development of multimodal molecular imaging probes. In this study, iron oxide/gold composite nanoparticles (NanoIOGs) were synthesized via the on-site reduction of an Au precursor salt by polyethyleneimine (PEI) molecules attached to iron oxide nanoparticles (IONPs), and they were employed in magnetic resonance and dark-field microscope imaging. PEI is considered as a polymeric active stabilizer (PAS), acting as a reducing agent for the synthesis of Au and a dispersant for nanoparticles. When the IONPs prepared at the PEI concentration of 0.02 wt. % were used for the NanoIOG synthesis, Au nanoseeds were formed around the IONPs. The alloy clusters of IONPs/Au crystals were produced with further reduction depending on PEI concentration. The NanoIOGs exhibited superparamagnetism in a magnetic field and plasmonic response in a dark-field (DF) microscope. The sizes, morphologies, magnetizations, and r2 relaxivities of NanoIOGs were affected significantly by the amount of PEI added during the NanoIOG synthesis. It is suggested that the PAS-mediated synthesis is simple and effective, and can be applied to various nanostructured Au-metal alloys. View Full-Text
Keywords: iron oxide; gold; molecular imaging; composite nanoparticles; polyethyleneimine; polymeric active stabilizer; nanoseeds; alloy clusters iron oxide; gold; molecular imaging; composite nanoparticles; polyethyleneimine; polymeric active stabilizer; nanoseeds; alloy clusters
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yoon, G.J.; Lee, S.Y.; Lee, S.B.; Park, G.Y.; Choi, J.H. Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe. Nanomaterials 2018, 8, 300.

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