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Nanomaterials 2018, 8(4), 205; https://doi.org/10.3390/nano8040205

Electrospun Composites of Polycaprolactone and Porous Silicon Nanoparticles for the Tunable Delivery of Small Therapeutic Molecules

1
Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia
2
Department of Chemistry, University College London, London WC1E 6BT, UK
3
MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
4
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia
5
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton 3168, Australia
*
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 26 March 2018 / Accepted: 27 March 2018 / Published: 29 March 2018
(This article belongs to the Special Issue Electrochemically Engineering of Nanoporous Materials)
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Abstract

This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytotoxic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics. View Full-Text
Keywords: porous silicon; drug delivery; electrospinning; poly(ε-caprolactone) porous silicon; drug delivery; electrospinning; poly(ε-caprolactone)
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McInnes, S.J.P.; Macdonald, T.J.; Parkin, I.P.; Nann, T.; Voelcker, N.H. Electrospun Composites of Polycaprolactone and Porous Silicon Nanoparticles for the Tunable Delivery of Small Therapeutic Molecules. Nanomaterials 2018, 8, 205.

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