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Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model

by 1,2 and 1,2,*
1
Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
2
Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing 400044, China
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(12), 999; https://doi.org/10.3390/nano8120999
Received: 27 October 2018 / Revised: 25 November 2018 / Accepted: 29 November 2018 / Published: 3 December 2018
Bone defects caused by fracture, disease or congenital defect remains a medically important problem to be solved. Bone tissue engineering (BTE) is a promising approach by providing scaffolds to guide and support the treatment of bone defects. However, the autologous bone graft has many defects such as limited sources and long surgical procedures. Therefore, xenograft bone graft is considered as one of the best substitutions and has been effectively used in clinical practice. Due to better preserved natural bone structure, suitable mechanical properties, low immunogenicity, good osteoinductivity and osteoconductivity in natural bone graft, decellularized and demineralized bone matrix (DBM) scaffolds were selected and discussed in the present review. In vivo animal models provide a complex physiological environment for understanding and evaluating material properties and provide important reference data for clinical trials. The purpose of this review is to outline the in vivo bone regeneration and remodeling capabilities of decellularized and DBM scaffolds in bone defect models to better evaluate the potential of these two types of scaffolds in BTE. Taking into account the limitations of the state-of-the-art technology, the results of the animal bone defect model also provide important information for future design of natural bone composite scaffolds. View Full-Text
Keywords: natural bone graft; decellularized bone matrix scaffold; demineralized bone matrix scaffold; animal defect model; bone reconstruction natural bone graft; decellularized bone matrix scaffold; demineralized bone matrix scaffold; animal defect model; bone reconstruction
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Liu, M.; Lv, Y. Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model. Nanomaterials 2018, 8, 999.

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