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The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation

Department of Stem Cell and Regenerative Biotechnology, Incurable Disease Animal Model & Stem Cell Institute (IDASI), Konkuk University, Seoul 05029, Korea
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(10), 761;
Received: 29 August 2018 / Revised: 22 September 2018 / Accepted: 25 September 2018 / Published: 26 September 2018
(This article belongs to the Special Issue Nanomaterials in Biocatalyst)
PDF [2811 KB, uploaded 26 September 2018]


Nanotechnology has a wide range of medical and industrial applications. The impact of metallic nanoparticles (NPs) on the proliferation and differentiation of normal, cancer, and stem cells is well-studied. The preparation of NPs, along with their physicochemical properties, is related to their biological function. Interestingly, various mechanisms are implicated in metallic NP-induced cellular proliferation and differentiation, such as modulation of signaling pathways, generation of reactive oxygen species, and regulation of various transcription factors. In this review, we will shed light on the biomedical application of metallic NPs and the interaction between NPs and the cellular components. The in vitro and in vivo influence of metallic NPs on stem cell differentiation and proliferation, as well as the mechanisms behind potential toxicity, will be explored. A better understanding of the limitations related to the application of metallic NPs on stem cell proliferation and differentiation will afford clues for optimal design and preparation of metallic NPs for the modulation of stem cell functions and for clinical application in regenerative medicine. View Full-Text
Keywords: metallic nanoparticles; stem cells; differentiation; proliferation; toxicity; regenerative medicine metallic nanoparticles; stem cells; differentiation; proliferation; toxicity; regenerative medicine

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Abdal Dayem, A.; Lee, S.B.; Cho, S.-G. The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation. Nanomaterials 2018, 8, 761.

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