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Open AccessArticle

Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs

1
Departament de Física, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Cerdanyola del Vallès, Spain
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Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Cerdanyola del Vallès, Spain
3
Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, E-08010 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2017, 7(7), 155; https://doi.org/10.3390/nano7070155
Received: 6 June 2017 / Revised: 21 June 2017 / Accepted: 22 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue Polymer Nanocomposites)
Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms. View Full-Text
Keywords: biodegradable material; porous membrane; drug delivery; hybrid material biodegradable material; porous membrane; drug delivery; hybrid material
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MDPI and ACS Style

Fornell, J.; Soriano, J.; Guerrero, M.; Sirvent, J.D.D.; Ferran-Marqués, M.; Ibáñez, E.; Barrios, L.; Baró, M.D.; Suriñach, S.; Nogués, C.; Sort, J.; Pellicer, E. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs. Nanomaterials 2017, 7, 155. https://doi.org/10.3390/nano7070155

AMA Style

Fornell J, Soriano J, Guerrero M, Sirvent JDD, Ferran-Marqués M, Ibáñez E, Barrios L, Baró MD, Suriñach S, Nogués C, Sort J, Pellicer E. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs. Nanomaterials. 2017; 7(7):155. https://doi.org/10.3390/nano7070155

Chicago/Turabian Style

Fornell, Jordina; Soriano, Jorge; Guerrero, Miguel; Sirvent, Juan D.D.; Ferran-Marqués, Marta; Ibáñez, Elena; Barrios, Leonardo; Baró, Maria D.; Suriñach, Santiago; Nogués, Carme; Sort, Jordi; Pellicer, Eva. 2017. "Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs" Nanomaterials 7, no. 7: 155. https://doi.org/10.3390/nano7070155

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