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Open AccessFeature PaperArticle

Heteromer Nanostars by Spontaneous Self-Assembly

1
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO 65409, USA
2
Department of Biological Sciences, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, MO 65409, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giuliana Gorrasi
Nanomaterials 2017, 7(6), 127; https://doi.org/10.3390/nano7060127
Received: 23 April 2017 / Revised: 17 May 2017 / Accepted: 23 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Polymer Nanocomposites)
Heteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), silver nitrate, and tetrakis(hydroxymethyl)phosphonium chloride (THPC). Mixing these reagents followed by UV irradiation successfully produced heteromer nanostars containing a number of arm chains attached to a single core with a high yield. The release of THPC from heteromer nanostars was tested for its potential use for breast cancer treatment. The nanostars present a unique geometrical design exhibiting a significant intracellular uptake by breast cancer cells but low cytotoxicity that potentiates its efficacy as drug carriers. View Full-Text
Keywords: nanostar; polylactide-co-glycolic acid (PLGA); star shape; tetrakis (hydroxylmethyl) phosphonium chloride (THPC) nanostar; polylactide-co-glycolic acid (PLGA); star shape; tetrakis (hydroxylmethyl) phosphonium chloride (THPC)
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MDPI and ACS Style

Brocker, C.; Kim, H.; Smith, D.; Barua, S. Heteromer Nanostars by Spontaneous Self-Assembly. Nanomaterials 2017, 7, 127. https://doi.org/10.3390/nano7060127

AMA Style

Brocker C, Kim H, Smith D, Barua S. Heteromer Nanostars by Spontaneous Self-Assembly. Nanomaterials. 2017; 7(6):127. https://doi.org/10.3390/nano7060127

Chicago/Turabian Style

Brocker, Caitlin; Kim, Hannah; Smith, Daniel; Barua, Sutapa. 2017. "Heteromer Nanostars by Spontaneous Self-Assembly" Nanomaterials 7, no. 6: 127. https://doi.org/10.3390/nano7060127

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