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Keywords = tetrakis (hydroxylmethyl) phosphonium chloride (THPC)

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11 pages, 2913 KiB  
Article
Heteromer Nanostars by Spontaneous Self-Assembly
by Caitlin Brocker, Hannah Kim, Daniel Smith and Sutapa Barua
Nanomaterials 2017, 7(6), 127; https://doi.org/10.3390/nano7060127 - 31 May 2017
Cited by 5 | Viewed by 5554
Abstract
Heteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), [...] Read more.
Heteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), silver nitrate, and tetrakis(hydroxymethyl)phosphonium chloride (THPC). Mixing these reagents followed by UV irradiation successfully produced heteromer nanostars containing a number of arm chains attached to a single core with a high yield. The release of THPC from heteromer nanostars was tested for its potential use for breast cancer treatment. The nanostars present a unique geometrical design exhibiting a significant intracellular uptake by breast cancer cells but low cytotoxicity that potentiates its efficacy as drug carriers. Full article
(This article belongs to the Special Issue Polymer Nanocomposites)
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