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Open AccessArticle

Hydroxyapatite Coated Iron Oxide Nanoparticles: A Promising Nanomaterial for Magnetic Hyperthermia Cancer Treatment

1
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
2
Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan 48513, Korea
3
Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 48513, Korea
4
Department of Otolaryngology—Head and Neck Surgery, Kosin University College of Medicine, Busan 602-702, Korea
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(12), 426; https://doi.org/10.3390/nano7120426
Received: 30 October 2017 / Revised: 22 November 2017 / Accepted: 28 November 2017 / Published: 4 December 2017
Targeting cancer cells without injuring normal cells is the prime objective in treatment of cancer. In this present study, solvothermal and wet chemical precipitation techniques were employed to synthesize iron oxide (IO), hydroxyapatite (HAp), and hydroxyapatite coated iron oxide (IO-HAp) nanoparticles for magnetic hyperthermia mediated cancer therapy. The synthesized well dispersed spherical IO-HAp nanoparticles, magnetite, and apatite phases were confirmed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and Field emission transmission electron microscopy (FETEM) with Energy Dispersive X-ray spectroscopy (EDS). The non-toxic behavior of synthesized IO-HAp nanoparticles was confirmed by cytotoxicity assay (Trypan blue and MTT assay). The synthesized nanoparticles revealed a remarkable magnetic saturation of 83.2 emu/g for IO and 40.6 emu/g for IO-HAp nanoparticles in presence of 15,000 Oe (1.5 T) magnetic field at room temperature (300 K). The magnetic hyperthermia study that was performed with IO-HAp nanoparticles showed an excellent hyperthermia effect (SAR value 85 W/g) over MG-63 osteosarcoma cells. The in vitro hyperthermia temperature (~45 °C) was reached within 3 min, which shows a very high efficiency and kills nearly all of the experimental MG-63 osteosarcoma cells within 30 min exposure. These results could potentially open new perceptions for biomaterials that are aimed for anti-cancer therapies based on magnetic hyperthermia. View Full-Text
Keywords: hydroxyapatite; iron oxide; hydroxyapatite coated iron oxide; magnetic hyperthermia; cancer therapy hydroxyapatite; iron oxide; hydroxyapatite coated iron oxide; magnetic hyperthermia; cancer therapy
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MDPI and ACS Style

Mondal, S.; Manivasagan, P.; Bharathiraja, S.; Santha Moorthy, M.; Nguyen, V.T.; Kim, H.H.; Nam, S.Y.; Lee, K.D.; Oh, J. Hydroxyapatite Coated Iron Oxide Nanoparticles: A Promising Nanomaterial for Magnetic Hyperthermia Cancer Treatment. Nanomaterials 2017, 7, 426.

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