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Open AccessArticle

Cationic Biomimetic Particles of Polystyrene/Cationic Bilayer/Gramicidin for Optimal Bactericidal Activity

Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, Brazil
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Nanomaterials 2017, 7(12), 422; https://doi.org/10.3390/nano7120422
Received: 30 October 2017 / Revised: 23 November 2017 / Accepted: 29 November 2017 / Published: 2 December 2017
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
Nanostructured particles of polystyrene sulfate (PSS) covered by a cationic lipid bilayer of dioctadecyldimethylammonium bromide (DODAB) incorporated gramicidin D (Gr) yielding optimal and broadened bactericidal activity against both Escherichia coli and Staphylococcus aureus. The adsorption of DODAB/Gr bilayer onto PSS nanoparticles (NPs) increased the zeta-average diameter by 8–10 nm, changed the zeta-potential of the NPs from negative to positive, and yielded a narrow size distributions for the PSS/DODAB/Gr NPs, which displayed broad and maximal microbicidal activity at very small concentrations of the antimicrobials, namely, 0.057 and 0.0057 mM DODAB and Gr, respectively. The results emphasized the advantages of highly-organized, nanostructured, and cationic particles to achieve hybrid combinations of antimicrobials with broad spectrum activity at considerably reduced DODAB and Gr concentrations. View Full-Text
Keywords: polystyrene sulfate; dioctadecyldimethylammonium bromide; cationic bilayer fragments; gramicidin D; nanostructured cationic particles; optimization of bactericidal activity; Escherichia coli; Staphylococcus aureus polystyrene sulfate; dioctadecyldimethylammonium bromide; cationic bilayer fragments; gramicidin D; nanostructured cationic particles; optimization of bactericidal activity; Escherichia coli; Staphylococcus aureus
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MDPI and ACS Style

Xavier, G.R.S.; Carmona-Ribeiro, A.M. Cationic Biomimetic Particles of Polystyrene/Cationic Bilayer/Gramicidin for Optimal Bactericidal Activity. Nanomaterials 2017, 7, 422.

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