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Doxorubicin-Wrapped Zinc Oxide Nanoclusters for the Therapy of Colorectal Adenocarcinoma

College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(11), 354;
Received: 28 September 2017 / Revised: 18 October 2017 / Accepted: 25 October 2017 / Published: 28 October 2017
PDF [2509 KB, uploaded 30 October 2017]


Doxorubicin (DOX)-wrapped zinc oxide nanoclusters (ZnO NCs) were developed for the therapy of colorectal cancer. DOX was coated onto the agglomerates of ZnO nanoparticles using a facile coating process. DOX-ZnO NCs with a hydrodynamic size of 170 nm, narrow size distribution, and positive zeta potential were fabricated. The aggregated shape of developed DOX-ZnO NCs was observed by transmission electron microscopy (TEM) imaging. The result of Fourier-transform infrared (FT-IR) analysis suggested the interaction between DOX and ZnO in DOX-ZnO NCs. The existence of DOX in the outer surface of DOX-ZnO NCs was further identified by X-ray powder diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) analyses. Cellular uptake efficiency and antiproliferation efficacy of developed DOX-ZnO NCs were tested in Caco-2 (human colorectal adenocarcinoma) cells. The cellular accumulated amount of DOX-ZnO NCs was 3.19-fold higher than that of free DOX (p < 0.05). The DOX-ZnO NCs group also exhibited improved antiproliferation potentials, compared with the DOX and ZnO groups, in Caco-2 cells at 0.5 and 1 μg/mL DOX concentrations. All these findings imply that developed DOX-ZnO NCs can be efficient hybrid nanoformulations for the therapy of colorectal cancers. View Full-Text
Keywords: anticancer activity; colorectal cancer; doxorubicin; nanocluster; zinc oxide anticancer activity; colorectal cancer; doxorubicin; nanocluster; zinc oxide

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Kim, S.; Lee, S.Y.; Cho, H.-J. Doxorubicin-Wrapped Zinc Oxide Nanoclusters for the Therapy of Colorectal Adenocarcinoma. Nanomaterials 2017, 7, 354.

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