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Open AccessFeature PaperArticle

Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy

1
Department of Chemistry and Center for NanoScience (CeNS), LMU Munich, Butenandtstraße 11 (E), 81377 Munich, Germany
2
School of Chemistry, Joseph Banks Laboratories, University of Lincoln, Lincoln LN67TS, UK
*
Authors to whom correspondence should be addressed.
Nanomaterials 2017, 7(11), 351; https://doi.org/10.3390/nano7110351
Received: 17 August 2017 / Revised: 16 October 2017 / Accepted: 20 October 2017 / Published: 26 October 2017
(This article belongs to the Special Issue Nanoparticles in Metal-Organic Frameworks)
One of the main problems for effective treatment of cancer is resistances, which often require combination therapy—for effective treatment. While there are already some potential drug carriers—e.g., liposomes, available for treatment—the effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy. View Full-Text
Keywords: metal-organic framework; nanoparticles; drug delivery; combination therapy metal-organic framework; nanoparticles; drug delivery; combination therapy
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Illes, B.; Wuttke, S.; Engelke, H. Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy. Nanomaterials 2017, 7, 351.

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