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Open AccessFeature PaperArticle

Nanometric MIL-125-NH2 Metal–Organic Framework as a Potential Nerve Agent Antidote Carrier

1
APMU, IMDEA Energy Institute, Avda. Ramón de la Sagra 3, E-28935 Móstoles, Madrid, Spain
2
Institut Lavoisier de Versailles, Université de Versailles St Quentin, UMR CNRS 8180, 45 Avenue des Etats-Unis, University Paris Saclay, 78035 Versailles, France
3
Institut Charles Gerhardt Montpellier UMR 5253 CNRS UM, Université Montpellier, Place E. Bataillon, 34095 Montpellier CEDEX 05, France
4
TNO, Lange Kleiweg 137, NL-2288GJ Rijswijk, The Netherlands
5
Institut des Matériaux Poreux de Paris, Ecole Normale Supérieure, Ecole Supérieure de Physique et de Chimie Industrielles de Paris, FRE CNRS 2000, PSL Research University, Paris 75005, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2017, 7(10), 321; https://doi.org/10.3390/nano7100321
Received: 21 July 2017 / Revised: 29 September 2017 / Accepted: 6 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue Nanoparticles in Metal-Organic Frameworks)
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and the release of drugs. The nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or pralidoxime) was effectively encapsulated into the pores of MIL-125-NH2 as a result of the interactions between 2-PAM and the pore walls being mediated by π-stacking and hydrogen bonds, as deduced from infrared spectroscopy and Monte Carlo simulation studies. Finally, colloidal solutions of MIL-125-NH2 nanoparticles exhibited remarkable stability in different organic media, aqueous solutions at different pH and under relevant physiological conditions over time (24 h). 2-PAM was rapidly released from the pores of MIL-125-NH2 in vitro. View Full-Text
Keywords: MIL-125-NH2; metal–organic frameworks; nanoparticles; colloidal stability; drug delivery; pralidoxime MIL-125-NH2; metal–organic frameworks; nanoparticles; colloidal stability; drug delivery; pralidoxime
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Vilela, S.M.F.; Salcedo-Abraira, P.; Colinet, I.; Salles, F.; De Koning, M.C.; Joosen, M.J.A.; Serre, C.; Horcajada, P. Nanometric MIL-125-NH2 Metal–Organic Framework as a Potential Nerve Agent Antidote Carrier. Nanomaterials 2017, 7, 321.

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