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Open AccessArticle

Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents

by Wenjun Le 1,†, Shaobin Cui 1,†, Xin Chen 1, Huanhuan Zhu 1, Bingdi Chen 1,2,* and Zheng Cui 1,3,*
1
The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
2
State Key Lab of Silicon Materials, Zhejiang University, Hangzhou 310027, China
3
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 28780, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Yurii Gun’ko
Nanomaterials 2016, 6(4), 65; https://doi.org/10.3390/nano6040065
Received: 4 February 2016 / Revised: 28 March 2016 / Accepted: 28 March 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Nanoparticles in Bioimaging)
Multi-modal imaging plays a key role in the earlier detection of disease. In this work, a facile bioinspired method was developed to synthesize Gd-functionalized gold nanoclusters (Gd-Au NCs). The Gd-Au NCs exhibit a uniform size, with an average size of 5.6 nm in dynamic light scattering (DLS), which is a bit bigger than gold clusters (3.74 nm, DLS), while the fluorescent properties of Gd-Au NCs are almost the same as that of Au NCs. Moreover, the Gd-Au NCs exhibit a high longitudinal relaxivity value (r1) of 22.111 s−1 per mM of Gd in phosphate-buffered saline (PBS), which is six times higher than that of commercial Magnevist (A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, Gd-DTPA, r1 = 3.56 mM−1·s−1). Besides, as evaluated by nano single photon emission computed tomography (SPECT) and computed tomography (CT) the Gd-Au NCs have a potential application as CT contrast agents because of the Au element. Finally, the Gd-Au NCs show little cytotoxicity, even when the Au concentration is up to 250 μM. Thus, the Gd-Au NCs can act as multi-modal imaging contrast agents. View Full-Text
Keywords: gold nanocluster; bovine serum albumin; contrast agent; magnetic resonance imaging; computed tomography gold nanocluster; bovine serum albumin; contrast agent; magnetic resonance imaging; computed tomography
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MDPI and ACS Style

Le, W.; Cui, S.; Chen, X.; Zhu, H.; Chen, B.; Cui, Z. Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents. Nanomaterials 2016, 6, 65.

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