T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis
1
Spanish Cardiovascular Research Centre (CNIC) and Spanish Pulmonary Diseases Network (CIBERES) C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain
2
Department of Physicochemistry II, Complutense University of Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Yurii Gun'ko
Nanomaterials 2015, 5(4), 1880-1890; https://doi.org/10.3390/nano5041880
Received: 7 October 2015
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Revised: 26 October 2015
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Accepted: 28 October 2015
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Published: 4 November 2015
Iron oxide nanoparticles have long been studied as a T2 contrast agent in MRI due to their superparamagnetic behavior. T1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
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Keywords:
iron oxide nanoparticles; MRI; T1 contrast; microwave
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MDPI and ACS Style
Bhavesh, R.; Lechuga-Vieco, A.V.; Ruiz-Cabello, J.; Herranz, F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials 2015, 5, 1880-1890. https://doi.org/10.3390/nano5041880
AMA Style
Bhavesh R, Lechuga-Vieco AV, Ruiz-Cabello J, Herranz F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials. 2015; 5(4):1880-1890. https://doi.org/10.3390/nano5041880
Chicago/Turabian StyleBhavesh, Riju, Ana V. Lechuga-Vieco, Jesús Ruiz-Cabello, and Fernando Herranz. 2015. "T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis" Nanomaterials 5, no. 4: 1880-1890. https://doi.org/10.3390/nano5041880
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