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Open AccessArticle

T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis

Spanish Cardiovascular Research Centre (CNIC) and Spanish Pulmonary Diseases Network (CIBERES) C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain
Department of Physicochemistry II, Complutense University of Madrid, 28040 Madrid, Spain
Author to whom correspondence should be addressed.
Academic Editor: Yurii Gun'ko
Nanomaterials 2015, 5(4), 1880-1890;
Received: 7 October 2015 / Revised: 26 October 2015 / Accepted: 28 October 2015 / Published: 4 November 2015
Iron oxide nanoparticles have long been studied as a T2 contrast agent in MRI due to their superparamagnetic behavior. T1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice. View Full-Text
Keywords: iron oxide nanoparticles; MRI; T1 contrast; microwave iron oxide nanoparticles; MRI; T1 contrast; microwave
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MDPI and ACS Style

Bhavesh, R.; Lechuga-Vieco, A.V.; Ruiz-Cabello, J.; Herranz, F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials 2015, 5, 1880-1890.

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