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Nanomaterials 2014, 4(2), 439-453;

Assessment of the Aerosol Generation and Toxicity of Carbon Nanotubes

The University of Iowa, Department of Occupational and Environmental Health, 100 CPHB S320, Iowa City, IA 52242, USA
Author to whom correspondence should be addressed.
Received: 31 March 2014 / Revised: 27 May 2014 / Accepted: 29 May 2014 / Published: 12 June 2014
(This article belongs to the Special Issue Nanotoxicology)
PDF [4197 KB, uploaded 12 June 2014]


Current interest in the pulmonary toxicity of carbon nanotubes (CNTs) has resulted in a need for an aerosol generation system that is capable of consistently producing a CNT aerosol at a desired concentration level. This two-part study was designed to: (1) assess the properties of a commercially-available aerosol generator when producing an aerosol from a purchased powder supply of double-walled carbon nanotubes (DWCNTs); and (2) assess the pulmonary sub-acute toxicity of DWCNTs in a murine model during a 5-day (4 h/day) whole-body exposure. The aerosol generator, consisting of a novel dustfeed mechanism and venturi ejector was determined to be capable of producing a DWCNT consistently over a 4 h exposure period at an average level of 10.8 mg/m3. The count median diameter was 121 nm with a geometric standard deviation of 2.04. The estimated deposited dose was 32 µg/mouse. The total number of cells in bronchoalveolar lavage (BAL) fluid was significantly (p < 0.01) increased in exposed mice compared to controls. Similarly, macrophages in BAL fluid were significantly elevated in exposed mice, but not neutrophils. All animals exposed to CNT and euthanized immediately after exposure had changes in the lung tissues showing acute inflammation and injury; however these pathological changes resolved two weeks after the exposure. View Full-Text
Keywords: carbon nanotubes; aerosol generation; pulmonary response; inhalation; toxicity carbon nanotubes; aerosol generation; pulmonary response; inhalation; toxicity

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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O'Shaughnessy, P.T.; Adamcakova-Dodd, A.; Altmaier, R.; Thorne, P.S. Assessment of the Aerosol Generation and Toxicity of Carbon Nanotubes. Nanomaterials 2014, 4, 439-453.

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