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Article

Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy

by
Ana Rita F. Pacheco
1,2,
Ana Margarida Barros
1,2,
Carlos O. Amorim
3,
Vítor S. Amaral
4,
Paulo J. G. Coutinho
1,2,
Ana Rita O. Rodrigues
1,2 and
Elisabete M. S. Castanheira
1,2,*
1
Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2
Associate Laboratory LaPMET, Campus de Gualtar, 4710-057 Braga, Portugal
3
Physics Department and i3N, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
4
Physics Department and CICECO, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Nanomaterials 2024, 14(8), 679; https://doi.org/10.3390/nano14080679
Submission received: 19 March 2024 / Revised: 11 April 2024 / Accepted: 12 April 2024 / Published: 15 April 2024
(This article belongs to the Special Issue Preparation, Characterization, Properties, Simulation, and Applications of Nanostructured Materials)
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Abstract

This work reports on the design, development, and characterization of novel magneto-plasmonic elastic liposomes (MPELs) of DPPC:SP80 (85:15) containing Mg0.75Ca0.25Fe2O4 nanoparticles coupled with gold nanorods, for topical application of photothermal therapy (PTT). Both magnetic and plasmonic components were characterized regarding their structural, morphological, magnetic and photothermal properties. The magnetic nanoparticles display a cubic shape and a size (major axis) of 37 ± 3 nm, while the longitudinal and transverse sizes of the nanorods are 46 ± 7 nm and 12 ± 1.6 nm, respectively. A new methodology was employed to couple the magnetic and plasmonic nanostructures, using cysteine as bridge. The potential for photothermia was evaluated for the magnetic nanoparticles, gold nanorods and the coupled magnetic/plasmonic nanoparticles, which demonstrated a maximum temperature variation of 28.9 °C, 33.6 °C and 37.2 °C, respectively, during a 30 min NIR-laser irradiation of 1 mg/mL dispersions. Using fluorescence anisotropy studies, a phase transition temperature (Tm) of 35 °C was estimated for MPELs, which ensures an enhanced fluidity crucial for effective crossing of the skin layers. The photothermal potential of this novel nanostructure corresponds to a specific absorption rate (SAR) of 616.9 W/g and a maximum temperature increase of 33.5 °C. These findings point to the development of thermoelastic nanocarriers with suitable features to act as photothermal hyperthermia agents.
Keywords: calcium/magnesium ferrite; gold nanorods; elastic liposomes; photothermia calcium/magnesium ferrite; gold nanorods; elastic liposomes; photothermia

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MDPI and ACS Style

Pacheco, A.R.F.; Barros, A.M.; Amorim, C.O.; Amaral, V.S.; Coutinho, P.J.G.; Rodrigues, A.R.O.; Castanheira, E.M.S. Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy. Nanomaterials 2024, 14, 679. https://doi.org/10.3390/nano14080679

AMA Style

Pacheco ARF, Barros AM, Amorim CO, Amaral VS, Coutinho PJG, Rodrigues ARO, Castanheira EMS. Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy. Nanomaterials. 2024; 14(8):679. https://doi.org/10.3390/nano14080679

Chicago/Turabian Style

Pacheco, Ana Rita F., Ana Margarida Barros, Carlos O. Amorim, Vítor S. Amaral, Paulo J. G. Coutinho, Ana Rita O. Rodrigues, and Elisabete M. S. Castanheira. 2024. "Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy" Nanomaterials 14, no. 8: 679. https://doi.org/10.3390/nano14080679

APA Style

Pacheco, A. R. F., Barros, A. M., Amorim, C. O., Amaral, V. S., Coutinho, P. J. G., Rodrigues, A. R. O., & Castanheira, E. M. S. (2024). Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy. Nanomaterials, 14(8), 679. https://doi.org/10.3390/nano14080679

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