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Polarization of Femtosecond Laser for Titanium Alloy Nanopatterning Influences Osteoblastic Differentiation
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Nanopatterning of Bionic Materials

Institute of Applied Physics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria
Nanomaterials 2023, 13(2), 233;
Submission received: 5 December 2022 / Accepted: 23 December 2022 / Published: 4 January 2023
(This article belongs to the Special Issue Nanopatterning of Bionic Materials)


The nanopatterning of bionic materials, performed by means of laser processes that utilize pulsed laser sources with short and ultrashort pulse durations, is a rapidly growing field. The method’s applications are varied, being used mainly to tailor special industrial, medical, and scientific applications. This process is significantly driven by the exciting properties of micro- and nanopatterned materials found in natural biological species. These include being self-cleaning, capable of adapting color and reflectivity, the possession of pronounced adhesive and anti-adhesive properties, the aptitude for wetting and directional fluid transport, reduction of wear and friction, control of cell growth, and antimicrobiotic properties [1].
This Special Issue, entitled “Nanopatterning of Bionic Materials”, represents an extension of the former review and includes a collection of recent top-quality articles in this research area. Particular attention has been devoted to the functionalization of medical implants and other surfaces, relevant for biomedical applications owing to the widespread need for improved approaches in medicine in our aging society. A comparable scenario applies for miniaturized sensors concerning the sensitivity of small traces of biologically hazardous or metabolic gases.
Herein, only original research articles have been considered for publication. The present Special Issue includes contributions on the following research topics:
Functionalization of Ti-based medical implants by means of laser-induced micro- and nanostructures for cell repellence as well as for osteoblastic proliferation and differentiation [2,3,4];
Polymer surfaces with antimicrobiotic and antiadhesive properties induced by laser-induced periodic surface structures (LIPSS) in connection with nanofibers or nanowires [5,6,7];
The generation of novel hybrid carbon nanotube materials for biosensing applications by means of laser-induced forward transfer (LIFT) [8].
Overall, I am grateful to all the authors for their fine contributions to the present Special Issue, and hope that the published studies will pave the way for the novel real-world applications of nanomaterials in medicine and biotechnology.


This article is part of the activities of the projects BioCombs4Nanofibers and LaserImplant. These projects have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862016 and 95173, respectively.


I am grateful to Editors of MDPI for their kind assistance in the organization of this Special Issue.

Conflicts of Interest

The author declares no conflict of interest. The funders had no role in the design of the article; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.


  1. Stratakis, E.; Bonse, J.; Heitz, J.; Siegel, J.; Tsibidis, G.D.; Skoulas, E.; Papadopoulos, A.; Mimidis, A.; Joel, A.C.; Comanns, P.; et al. Laser engineering of biomimetic surfaces. Mater. Sci. Eng. R 2020, 141, 100562. [Google Scholar] [CrossRef]
  2. Muck, M.; Wolfsjäger, B.; Seibert, K.; Maier, C.; Lone, S.A.; Hassel, A.W.; Baumgartner, W.; Heitz, J. Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization. Nanomaterials 2021, 11, 1342. [Google Scholar] [CrossRef] [PubMed]
  3. Maalouf, M.; Abou Khalil, A.; Di Maio, Y.; Papa, S.; Sedao, X.; Dalix, E.; Peyroche, S.; Guignandon, A.; Dumas, V. Polarization of Femtosecond Laser for Titanium Alloy Nanopatterning Influences Osteoblastic Differentiation. Nanomaterials 2022, 12, 1619. [Google Scholar] [CrossRef] [PubMed]
  4. Vlahou, M.; Fraggelakis, F.; Manganas, P.; Tsibidis, G.D.; Ranella, A.; Stratakis, E. Fabrication of Biomimetic 2D Nanostructures through Irradiation of Stainless Steel Surfaces with Double Femtosecond Pulses. Nanomaterials 2022, 12, 623. [Google Scholar] [CrossRef] [PubMed]
  5. Pryjmaková, J.; Kaimlová, M.; Vokatá, B.; Hubáček, T.; Slepička, P.; Švorčík, V.; Siegel, J. Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials. Nanomaterials 2021, 11, 2285. [Google Scholar] [CrossRef] [PubMed]
  6. Richter, A.M.; Buchberger, G.; Stifter, D.; Duchoslav, J.; Hertwig, A.; Bonse, J.; Heitz, J.; Schwibbert, K. Spatial Period of Laser-Induced Surface Nanoripples on PET Determines Escherichia coli Repellence. Nanomaterials 2021, 11, 3000. [Google Scholar] [CrossRef] [PubMed]
  7. Meyer, M.; Buchberger, G.; Heitz, J.; Baiko, D.; Joel, A.-C. Ambient Climate Influences Anti-Adhesion between Biomimetic Structured Foil and Nanofibers. Nanomaterials 2021, 11, 3222. [Google Scholar] [CrossRef] [PubMed]
  8. Bonciu, A.F.; Filipescu, M.; Voicu, S.I.; Lippert, T.; Palla-Papavlu, A. Facile Fabrication of Hybrid Carbon Nanotube Sensors by Laser Direct Transfer. Nanomaterials 2021, 11, 2604. [Google Scholar] [CrossRef] [PubMed]
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Heitz, J. Nanopatterning of Bionic Materials. Nanomaterials 2023, 13, 233.

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Heitz J. Nanopatterning of Bionic Materials. Nanomaterials. 2023; 13(2):233.

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Heitz, Johannes. 2023. "Nanopatterning of Bionic Materials" Nanomaterials 13, no. 2: 233.

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