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Nanomaterials
Volume 13
Issue 17
10.3390/nano13172476
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Review

Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics

by
Palmira Alessia Cavallaro
1,†,
Marzia De Santo
1,†,
Emilia Lucia Belsito
1,
Camilla Longobucco
1,
Manuela Curcio
1,
Catia Morelli
1,
Luigi Pasqua
2,* and
Antonella Leggio
1,*
1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, Italy
2
Department of Environmental Engineering, University of Calabria, Via P. Bucci, 87036 Rende, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nanomaterials 2023, 13(17), 2476; https://doi.org/10.3390/nano13172476
Submission received: 28 July 2023 / Revised: 27 August 2023 / Accepted: 29 August 2023 / Published: 1 September 2023
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Abstract

Breast cancer represents the most common cancer type and one of the major leading causes of death in the female worldwide population. Overexpression of HER2, a transmembrane glycoprotein related to the epidermal growth factor receptor, results in a biologically and clinically aggressive breast cancer subtype. It is also the primary driver for tumor detection and progression and, in addition to being an important prognostic factor in women diagnosed with breast cancer, HER2 is a widely known therapeutic target for drug development. The aim of this review is to provide an updated overview of the main approaches for the diagnosis and treatment of HER2-positive breast cancer proposed in the literature over the past decade. We focused on the different targeting strategies involving antibodies and peptides that have been explored with their relative outcomes and current limitations that need to be improved. The review also encompasses a discussion on targeted peptides acting as probes for molecular imaging. By using different types of HER2-targeting strategies, nanotechnology promises to overcome some of the current clinical challenges by developing novel HER2-guided nanosystems suitable as powerful tools in breast cancer imaging, targeting, and therapy.
Keywords: targeting peptides; HER2-positive breast cancer; monoclonal antibodies; nanoparticles; drug delivery; tumor imaging targeting peptides; HER2-positive breast cancer; monoclonal antibodies; nanoparticles; drug delivery; tumor imaging
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MDPI and ACS Style

Cavallaro, P.A.; De Santo, M.; Belsito, E.L.; Longobucco, C.; Curcio, M.; Morelli, C.; Pasqua, L.; Leggio, A. Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics. Nanomaterials 2023, 13, 2476. https://doi.org/10.3390/nano13172476

AMA Style

Cavallaro PA, De Santo M, Belsito EL, Longobucco C, Curcio M, Morelli C, Pasqua L, Leggio A. Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics. Nanomaterials. 2023; 13(17):2476. https://doi.org/10.3390/nano13172476

Chicago/Turabian Style

Cavallaro, Palmira Alessia, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, and Antonella Leggio. 2023. "Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics" Nanomaterials 13, no. 17: 2476. https://doi.org/10.3390/nano13172476

APA Style

Cavallaro, P. A., De Santo, M., Belsito, E. L., Longobucco, C., Curcio, M., Morelli, C., Pasqua, L., & Leggio, A. (2023). Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics. Nanomaterials, 13(17), 2476. https://doi.org/10.3390/nano13172476

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