Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation Process of PSBMA Nanogels
2.3. Drug Loading
2.4. Hydrogel Preparation
2.5. Characterization
2.5.1. Structure Characterization
2.5.2. Particle Size Measurement
2.5.3. Stability Characterization
2.5.4. Morphological Observation
2.5.5. Transmittance
2.5.6. Water Contact Angle
2.5.7. Equilibrium Water Content
2.5.8. Swelling Properties
2.5.9. Mechanical Properties
2.6. In Vitro Drug Release
2.7. Cell Culture and Toxicity Test
3. Results
3.1. Preparation and Characterization of PSBMA Nanogels
3.2. Drug Encapsulation in Nanogels
3.3. Synthesis and Characterization of Nanogel-Embedded Contact Lenses
3.4. In Vitro Drug Release of Nanogels and Nanogel-Embedded Contact Lens
3.5. In Vitro Cytotoxicity Study
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Sample | SBMA (mg) | DVB (mg) | AIBN (mg) | AN (mL) | Size (nm) a | PDI b | ZP (mV) c |
---|---|---|---|---|---|---|---|
PSBMA-1 | 180 | 20 | 4 | 40 | 294.7 ± 2.6 | 0.183 | −4.3 ± 0.7 |
PSBMA-2 | 160 | 40 | 4 | 40 | 270.4 ± 3.6 | 0.124 | −9.2 ± 1.3 |
PSBMA-3 | 140 | 60 | 4 | 40 | 248.6 ± 2.2 | 0.164 | −11.4 ± 1.5 |
PSBMA-4 | 120 | 80 | 4 | 40 | 219.9 ± 1.7 | 0.104 | −14.2 ± 1.8 |
Sample | NVP (mg) | HEMA (mg) | EGDMA (mg) | AIBN (mg) | Drug-Loaded Nanogels (mg) | Loaded LEV (mg) a |
---|---|---|---|---|---|---|
pHEMA | 150 | 815 | 15 | 20 | 0 | 0 |
pHEMA/LEV-1 | 150 | 815 | 15 | 20 | 50 | 6.7 |
pHEMA/LEV-2 | 150 | 815 | 15 | 20 | 80 | 10.6 |
pHEMA/LEV-3 | 150 | 815 | 15 | 20 | 110 | 14.6 |
pHEMA/LEV-4 | 150 | 815 | 15 | 20 | 130 | 17.3 |
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Wang, Z.; Li, X.; Zhang, X.; Sheng, R.; Lin, Q.; Song, W.; Hao, L. Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery. Nanomaterials 2021, 11, 2328. https://doi.org/10.3390/nano11092328
Wang Z, Li X, Zhang X, Sheng R, Lin Q, Song W, Hao L. Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery. Nanomaterials. 2021; 11(9):2328. https://doi.org/10.3390/nano11092328
Chicago/Turabian StyleWang, Zhao, Xinhua Li, Xiaojuan Zhang, Ruilong Sheng, Qing Lin, Wenli Song, and Lingyun Hao. 2021. "Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery" Nanomaterials 11, no. 9: 2328. https://doi.org/10.3390/nano11092328