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Article

Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization

1
Institute of Applied Physics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria
2
Hofer GmbH & Co KG, Jahnstrasse 10-12, 8280 Fürstenfeld, Austria
3
Institute of Chemical Technology of Inorganic Materials, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria
4
Institute of Biomedical Mechatronics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Ion N. Mihailescu
Nanomaterials 2021, 11(5), 1342; https://doi.org/10.3390/nano11051342
Received: 26 April 2021 / Revised: 17 May 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Nanopatterning of Bionic Materials)
Microstructures and nanostructures can be used to reduce the adhesion of the cells on the auxiliary material. Therefore, the aim of our work was to fabricate laser-induced hierarchical microstructures and nanostructures by femtosecond laser-treatment (wavelength 1040 nm, pulse length 350 fs, repetition rates in the kHz range) to reduce the cell adhesion. Additionally, surface chemistry modification by optimized electrochemical anodization was used to further reduce the cell adhesion. For testing, flat plates and bone screws made of Ti-6Al-4V were used. Bone-forming cells (human osteoblasts from the cell line SAOS-2) were grown on the bone implants and additional test samples for two to three weeks. After the growth period, the cells were characterized by scanning electron microscopy (SEM). While earlier experiments with fibroblasts had shown that femtosecond laser-processing followed by electrochemical anodization had a significant impact on cell adhesion reduction, for osteoblasts the same conditions resulted in an activation of the cells with increased production of extracellular matrix material. Significant reduction of cell adhesion for osteoblasts was only obtained at pre-anodized surfaces. It could be demonstrated that this functionalization by means of femtosecond laser-processing can result in bone screws that hinder the adhesion of osteoblasts. View Full-Text
Keywords: ultrafast laser-processing; laser-induced microstructures and nanostructures; cell activation; cell-repellent surfaces; medical implants ultrafast laser-processing; laser-induced microstructures and nanostructures; cell activation; cell-repellent surfaces; medical implants
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MDPI and ACS Style

Muck, M.; Wolfsjäger, B.; Seibert, K.; Maier, C.; Lone, S.A.; Hassel, A.W.; Baumgartner, W.; Heitz, J. Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization. Nanomaterials 2021, 11, 1342. https://doi.org/10.3390/nano11051342

AMA Style

Muck M, Wolfsjäger B, Seibert K, Maier C, Lone SA, Hassel AW, Baumgartner W, Heitz J. Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization. Nanomaterials. 2021; 11(5):1342. https://doi.org/10.3390/nano11051342

Chicago/Turabian Style

Muck, Martina, Benedikt Wolfsjäger, Karoline Seibert, Christian Maier, Shaukat A. Lone, Achim W. Hassel, Werner Baumgartner, and Johannes Heitz. 2021. "Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization" Nanomaterials 11, no. 5: 1342. https://doi.org/10.3390/nano11051342

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