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Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer

Chemical and Life Science Engineering Department, Virginia Commonwealth University, Richmond, VA 23284, USA
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Author to whom correspondence should be addressed.
Academic Editor: Jose L. Luque-Garcia
Nanomaterials 2021, 11(4), 1048; https://doi.org/10.3390/nano11041048
Received: 18 March 2021 / Revised: 10 April 2021 / Accepted: 12 April 2021 / Published: 20 April 2021
(This article belongs to the Section Biology and Medicines)
Treatment of ovarian cancer is challenging due to late stage diagnosis, acquired drug resistance mechanisms, and systemic toxicity of chemotherapeutic agents. Combination chemotherapy has the potential to enhance treatment efficacy by activation of multiple downstream pathways to overcome drug resistance and reducing required dosages. Sequence of delivery and the dosing schedule can further enhance treatment efficacy. Formulation of drug combinations into nanoparticles can further enhance treatment efficacy. Due to their versatility, polymer-based nanoparticles are an especially promising tool for clinical translation of combination therapies with tunable dosing schedules. We review polymer nanoparticle (e.g., micelles, dendrimers, and lipid nanoparticles) carriers of drug combinations formulated to treat ovarian cancer. In particular, the focus on this review is combinations of platinum and taxane agents (commonly used first line treatments for ovarian cancer) combined with other small molecule therapeutic agents. In vitro and in vivo drug potency are discussed with a focus on quantifiable synergistic effects. The effect of drug sequence and dosing schedule is examined. Computational approaches as a tool to predict synergistic drug combinations and dosing schedules as a tool for future nanoparticle design are also briefly discussed. View Full-Text
Keywords: polymer; drug delivery; cancer; combination chemotherapy; nanocarrier; therapeutic efficacy; ovarian carcinoma; synergy polymer; drug delivery; cancer; combination chemotherapy; nanocarrier; therapeutic efficacy; ovarian carcinoma; synergy
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MDPI and ACS Style

Levit, S.L.; Tang, C. Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer. Nanomaterials 2021, 11, 1048. https://doi.org/10.3390/nano11041048

AMA Style

Levit SL, Tang C. Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer. Nanomaterials. 2021; 11(4):1048. https://doi.org/10.3390/nano11041048

Chicago/Turabian Style

Levit, Shani L., and Christina Tang. 2021. "Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer" Nanomaterials 11, no. 4: 1048. https://doi.org/10.3390/nano11041048

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