Next Article in Journal
Preparation of Cobalt Oxide–Reduced Graphitic Oxide Supercapacitor Electrode by Photothermal Processing
Next Article in Special Issue
Selective Oxidation of Transient Organic Radicals in the Presence of Gold Nanoparticles
Previous Article in Journal
Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate
Previous Article in Special Issue
On the Primary Water Radicals’ Production in the Presence of Gold Nanoparticles: Electron Pulse Radiolysis Study
Article

Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging

1
Takasaki Advanced Radiation Research Institute (TARRI), National Institutes for Quantum and Radiological Science and Technology (QST), 1233 Watanuki-Machi, Takasaki, Gunma 370-1292, Japan
2
Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjintyo, Kiryu, Gunma 376-8515, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Gérard Baldacchino
Nanomaterials 2021, 11(3), 714; https://doi.org/10.3390/nano11030714
Received: 20 February 2021 / Revised: 5 March 2021 / Accepted: 10 March 2021 / Published: 12 March 2021
Nanoparticles have been employed to develop nanosensors and drug carriers that accumulate in tumors. Thus, it is necessary to control the particle size, surface potential, and biodegradability of these nanoparticles for effective tumor accumulation and safe medical application. In this study, to form a nanoparticle platform suitable for diagnostic and drug delivery system (DDS) applications, peptides composed of aromatic amino acid residues were designed and synthesized based on the radiation crosslinking mechanism of proteins. The peptide nanoparticles, which were produced by γ-ray irradiation, displayed a positive surface potential, maintained biodegradability, and were stable in water and phosphoric buffer solution during actual diagnosis. The surface potential of the peptide nanoparticles could be changed to negative by using a fluorescent labeling reagent, so that the fluorescent-labeled peptide nanoparticles were uptaken by HeLa cells. The radiation-crosslinked nanoparticles can be applied as a platform for tumor-targeting diagnostics and DDS therapy. View Full-Text
Keywords: peptide; nanoparticle; radiation crosslinking; γ-rays; tumor diagnostics peptide; nanoparticle; radiation crosslinking; γ-rays; tumor diagnostics
Show Figures

Figure 1

MDPI and ACS Style

Kimura, A.; Ueno, M.; Arai, T.; Oyama, K.; Taguchi, M. Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging. Nanomaterials 2021, 11, 714. https://doi.org/10.3390/nano11030714

AMA Style

Kimura A, Ueno M, Arai T, Oyama K, Taguchi M. Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging. Nanomaterials. 2021; 11(3):714. https://doi.org/10.3390/nano11030714

Chicago/Turabian Style

Kimura, Atsushi, Miho Ueno, Tadashi Arai, Kotaro Oyama, and Mitsumasa Taguchi. 2021. "Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging" Nanomaterials 11, no. 3: 714. https://doi.org/10.3390/nano11030714

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop