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Article

SiO2-Ag Composite as a Highly Virucidal Material: A Roadmap that Rapidly Eliminates SARS-CoV-2

1
CDMF, LIEC, Federal University of São Carlos—(UFSCar), 13565-905 São Carlos, SP, Brazil
2
Department of Physical and Analytical Chemistry, University Jaume I (UJI), 12071 Castellon, Spain
3
Nanox Tecnologia S/A, 13562-400 São Carlos, SP, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Miguel Gama and Francesco Paolo La Mantia
Nanomaterials 2021, 11(3), 638; https://doi.org/10.3390/nano11030638
Received: 7 February 2021 / Revised: 22 February 2021 / Accepted: 26 February 2021 / Published: 4 March 2021
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
COVID-19, as the cause of a global pandemic, has resulted in lockdowns all over the world since early 2020. Both theoretical and experimental efforts are being made to find an effective treatment to suppress the virus, constituting the forefront of current global safety concerns and a significant burden on global economies. The development of innovative materials able to prevent the transmission, spread, and entry of COVID-19 pathogens into the human body is currently in the spotlight. The synthesis of these materials is, therefore, gaining momentum, as methods providing nontoxic and environmentally friendly procedures are in high demand. Here, a highly virucidal material constructed from SiO2-Ag composite immobilized in a polymeric matrix (ethyl vinyl acetate) is presented. The experimental results indicated that the as-fabricated samples exhibited high antibacterial activity towards Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as well as towards SARS-CoV-2. Based on the present results and radical scavenger experiments, we propose a possible mechanism to explain the enhancement of the biocidal activity. In the presence of O2 and H2O, the plasmon-assisted surface mechanism is the major reaction channel generating reactive oxygen species (ROS). We believe that the present strategy based on the plasmonic effect would be a significant contribution to the design and preparation of efficient biocidal materials. This fundamental research is a precedent for the design and application of adequate technology to the next-generation of antiviral surfaces to combat SARS-CoV-2. View Full-Text
Keywords: COVID-19; virus elimination; antiviral surfaces; SiO2-Ag composite; ethyl vinyl acetate; surface plasmon resonance effect COVID-19; virus elimination; antiviral surfaces; SiO2-Ag composite; ethyl vinyl acetate; surface plasmon resonance effect
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MDPI and ACS Style

Assis, M.; Simoes, L.G.P.; Tremiliosi, G.C.; Coelho, D.; Minozzi, D.T.; Santos, R.I.; Vilela, D.C.B.; Santos, J.R.d.; Ribeiro, L.K.; Rosa, I.L.V.; Mascaro, L.H.; Andrés, J.; Longo, E. SiO2-Ag Composite as a Highly Virucidal Material: A Roadmap that Rapidly Eliminates SARS-CoV-2. Nanomaterials 2021, 11, 638. https://doi.org/10.3390/nano11030638

AMA Style

Assis M, Simoes LGP, Tremiliosi GC, Coelho D, Minozzi DT, Santos RI, Vilela DCB, Santos JRd, Ribeiro LK, Rosa ILV, Mascaro LH, Andrés J, Longo E. SiO2-Ag Composite as a Highly Virucidal Material: A Roadmap that Rapidly Eliminates SARS-CoV-2. Nanomaterials. 2021; 11(3):638. https://doi.org/10.3390/nano11030638

Chicago/Turabian Style

Assis, Marcelo, Luiz G.P. Simoes, Guilherme C. Tremiliosi, Dyovani Coelho, Daniel T. Minozzi, Renato I. Santos, Daiane C.B. Vilela, Jeziel R.d. Santos, Lara K. Ribeiro, Ieda L.V. Rosa, Lucia H. Mascaro, Juan Andrés, and Elson Longo. 2021. "SiO2-Ag Composite as a Highly Virucidal Material: A Roadmap that Rapidly Eliminates SARS-CoV-2" Nanomaterials 11, no. 3: 638. https://doi.org/10.3390/nano11030638

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