Next Article in Journal
Comparison of Nanomaterials with Other Unconventional Materials Used as Additives for Soil Improvement in the Context of Sustainable Development: A Review
Next Article in Special Issue
Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy
Previous Article in Journal
Cell Volume (3D) Correlative Microscopy Facilitated by Intracellular Fluorescent Nanodiamonds as Multi-Modal Probes
Previous Article in Special Issue
Gold Nanoparticle-Assisted Virus Formation by Means of the Delivery of an Oncolytic Adenovirus Genome
Review

Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications

1
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
2
Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria
3
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
4
Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, Buldhana 443101, Maharashtra, India
5
Department of Pharmaceutical Chemistry, H R Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist Dhule 425405, Maharashtra, India
*
Author to whom correspondence should be addressed.
Nanomaterials 2021, 11(1), 13; https://doi.org/10.3390/nano11010013
Received: 6 November 2020 / Revised: 9 December 2020 / Accepted: 19 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Nanomedicine in Drug Delivery)
Black phosphorus is one of the emerging members of two-dimensional (2D) materials which has recently entered the biomedical field. Its anisotropic properties and infrared bandgap have enabled researchers to discover its applicability in several fields including optoelectronics, 3D printing, bioimaging, and others. Characterization techniques such as Raman spectroscopy have revealed the structural information of Black phosphorus (BP) along with its fundamental properties, such as the behavior of its photons and electrons. The present review provides an overview of synthetic approaches and properties of BP, in addition to a detailed discussion about various types of surface modifications available for overcoming the stability-related drawbacks and for imparting targeting ability to synthesized nanoplatforms. The review further gives an overview of multiple characterization techniques such as spectroscopic, thermal, optical, and electron microscopic techniques for providing an insight into its fundamental properties. These characterization techniques are not only important for the analysis of the synthesized BP but also play a vital role in assessing the doping as well as the structural integrity of BP-based nanocomposites. The potential role of BP and BP-based nanocomposites for biomedical applications specifically, in the fields of drug delivery, 3D printing, and wound dressing, have been discussed in detail to provide an insight into the multifunctional role of BP-based nanoplatforms for the management of various diseases, including cancer therapy. The review further sheds light on the role of BP-based 2D platforms such as BP nanosheets along with BP-based 0D platforms—i.e., BP quantum dots in the field of therapy and bioimaging of cancer using techniques such as photoacoustic imaging and fluorescence imaging. Although the review inculcates the multimodal therapeutic as well as imaging role of BP, there is still research going on in this field which will help in the development of BP-based theranostic platforms not only for cancer therapy, but various other diseases. View Full-Text
Keywords: bioimaging; wound healing; 3D printing; surface modification; characterization bioimaging; wound healing; 3D printing; surface modification; characterization
Show Figures

Graphical abstract

MDPI and ACS Style

Pandey, A.; Nikam, A.N.; Fernandes, G.; Kulkarni, S.; Padya, B.S.; Prassl, R.; Das, S.; Joseph, A.; Deshmukh, P.K.; Patil, P.O.; Mutalik, S. Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications. Nanomaterials 2021, 11, 13. https://doi.org/10.3390/nano11010013

AMA Style

Pandey A, Nikam AN, Fernandes G, Kulkarni S, Padya BS, Prassl R, Das S, Joseph A, Deshmukh PK, Patil PO, Mutalik S. Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications. Nanomaterials. 2021; 11(1):13. https://doi.org/10.3390/nano11010013

Chicago/Turabian Style

Pandey, Abhijeet, Ajinkya N. Nikam, Gasper Fernandes, Sanjay Kulkarni, Bharath S. Padya, Ruth Prassl, Subham Das, Alex Joseph, Prashant K. Deshmukh, Pravin O. Patil, and Srinivas Mutalik. 2021. "Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications" Nanomaterials 11, no. 1: 13. https://doi.org/10.3390/nano11010013

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop