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Article

Fluorescent, Prussian Blue-Based Biocompatible Nanoparticle System for Multimodal Imaging Contrast

1
Department of Biophysics and Radiation Biology, Semmelweis University, 1085 Budapest, Hungary
2
Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 1117 Budapest, Hungary
3
Department of Pharmaceutics, Semmelweis University, 1085 Budapest, Hungary
4
Institute of Radiochemistry and Radioecology, University of Pannonia, 8200 Veszprém, Hungary
5
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore
6
In Vivo Imaging Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, 6723 Szeged, Hungary
7
CROmed Translational Research Centers, 1047 Budapest, Hungary
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(9), 1732; https://doi.org/10.3390/nano10091732
Received: 16 July 2020 / Revised: 21 August 2020 / Accepted: 27 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Nanomaterials for Contrast Agent and Biomedical Imaging)
(1) Background. The main goal of this work was to develop a fluorescent dye-labelling technique for our previously described nanosized platform, citrate-coated Prussian blue (PB) nanoparticles (PBNPs). In addition, characteristics and stability of the PB nanoparticles labelled with fluorescent dyes were determined. (2) Methods. We adsorbed the fluorescent dyes Eosin Y and Rhodamine B and methylene blue (MB) to PB-nanoparticle systems. The physicochemical properties of these fluorescent dye-labeled PBNPs (iron(II);iron(III);octadecacyanide) were determined using atomic force microscopy, dynamic light scattering, zeta potential measurements, scanning- and transmission electron microscopy, X-ray diffraction, and Fourier-transformation infrared spectroscopy. A methylene-blue (MB) labelled, polyethylene-glycol stabilized PBNP platform was selected for further assessment of in vivo distribution and fluorescent imaging after intravenous administration in mice. (3) Results. The MB-labelled particles emitted a strong fluorescent signal at 662 nm. We found that the fluorescent light emission and steric stabilization made this PBNP-MB particle platform applicable for in vivo optical imaging. (4) Conclusion. We successfully produced a fluorescent and stable, Prussian blue-based nanosystem. The particles can be used as a platform for imaging contrast enhancement. In vivo stability and biodistribution studies revealed new aspects of the use of PBNPs. View Full-Text
Keywords: Prussian blue nanoparticles; fluorescent imaging; optical imaging; biocompatible Prussian blue nanoparticles; fluorescent imaging; optical imaging; biocompatible
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MDPI and ACS Style

Forgách, L.; Hegedűs, N.; Horváth, I.; Kiss, B.; Kovács, N.; Varga, Z.; Jakab, G.; Kovács, T.; Padmanabhan, P.; Szigeti, K.; Máthé, D. Fluorescent, Prussian Blue-Based Biocompatible Nanoparticle System for Multimodal Imaging Contrast. Nanomaterials 2020, 10, 1732. https://doi.org/10.3390/nano10091732

AMA Style

Forgách L, Hegedűs N, Horváth I, Kiss B, Kovács N, Varga Z, Jakab G, Kovács T, Padmanabhan P, Szigeti K, Máthé D. Fluorescent, Prussian Blue-Based Biocompatible Nanoparticle System for Multimodal Imaging Contrast. Nanomaterials. 2020; 10(9):1732. https://doi.org/10.3390/nano10091732

Chicago/Turabian Style

Forgách, László, Nikolett Hegedűs, Ildikó Horváth, Bálint Kiss, Noémi Kovács, Zoltán Varga, Géza Jakab, Tibor Kovács, Parasuraman Padmanabhan, Krisztián Szigeti, and Domokos Máthé. 2020. "Fluorescent, Prussian Blue-Based Biocompatible Nanoparticle System for Multimodal Imaging Contrast" Nanomaterials 10, no. 9: 1732. https://doi.org/10.3390/nano10091732

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