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Article

The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond

1
Advanced Research Laboratories, Tokyo City University, Tokyo 158-8557, Japan
2
Graduate School of Information Technology, Kobe Institute of Computing, Kobe 650-0001, Japan
3
Graduate School of Education, Kyoto University, Kyoto 606-8501, Japan
4
Graduate School of Global Environmental Studies, Sophia University, Tokyo 102-8554, Japan
5
Graduate School of Integrative Science and Engineering, Electrical Engineering and Chemistry, Tokyo City University, Tokyo 158-8557, Japan
6
Clinic F Laser Medicine & Surgery, Tokyo 102-0083, Japan
7
Osaka City University, Osaka 558-8585, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(9), 1699; https://doi.org/10.3390/nano10091699
Received: 24 July 2020 / Revised: 16 August 2020 / Accepted: 27 August 2020 / Published: 29 August 2020
(This article belongs to the Special Issue Frontiers in Nanotoxicology)
There are currently no promising therapy strategies for either the treatment or prevention of novel coronavirus disease 2019 (COVID-19), despite the urgent need. In addition to respiratory diseases, vascular complications are rapidly emerging as a key threat of COVID-19. Existing nitric oxide (NO) therapies have been shown to improve the vascular system; however, they have different limitations in terms of safety, usability and availability. In light of this, we hypothesise that a natural-mineral-based novel nanomaterial, which was developed based on NO therapy, might be a viable strategy for the treatment and prevention of COVID-19. The present study examined if it could induce an increase of intravascular NO, vasodilation and the consequent increase of blood flow rate and temperature in a living body. The intravascular NO concentration in the hepatic portal of rats was increased by 0.17 nM over 35.2 s on average after its application. An ultrasonic Doppler flow meter showed significant increases in the blood flow rate and vessel diameter, but no difference in the blood flow velocity. These were corroborated by measurements of human hand surface temperature. To our knowledge, this result is the first evidence where an increase of intravascular NO and vasodilation were induced by bringing a natural-mineral-based nanomaterial into contact with or close to a living body. The precise mechanisms remain a matter for further investigation; however, we may assume that endothelial NO synthase, haemoglobin and endothelium-derived hyperpolarising factor are deeply involved in the increase of intravascular NO. View Full-Text
Keywords: SARS-CoV-2; COVID-19; natural-mineral-based nanomaterial; nitric oxide; haemoglobin; blood flow promotion SARS-CoV-2; COVID-19; natural-mineral-based nanomaterial; nitric oxide; haemoglobin; blood flow promotion
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MDPI and ACS Style

Akiyama, T.; Hirata, T.; Fujimoto, T.; Hatakeyama, S.; Yamazaki, R.; Nomura, T. The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond. Nanomaterials 2020, 10, 1699. https://doi.org/10.3390/nano10091699

AMA Style

Akiyama T, Hirata T, Fujimoto T, Hatakeyama S, Yamazaki R, Nomura T. The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond. Nanomaterials. 2020; 10(9):1699. https://doi.org/10.3390/nano10091699

Chicago/Turabian Style

Akiyama, Tomohiro, Takamichi Hirata, Takahiro Fujimoto, Shinnosuke Hatakeyama, Ryuhei Yamazaki, and Tomohiro Nomura. 2020. "The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond" Nanomaterials 10, no. 9: 1699. https://doi.org/10.3390/nano10091699

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