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Article

Hydroxyapatite Surfaces Functionalized with a Self-Assembling Peptide: XPS, RAIRS and NEXAFS Study

1
Department of Science, Roma Tre University, Via della Vasca Navale 79, 00146 Rome, Italy
2
Department of Materials Science, University of Milano-Bicocca, Via Cozzi 55, 20125 Milan, Italy
3
Institute of Structure of Matter (ISM), National Research Council (CNR), Via Fosso del Cavaliere 100, 00133 Rome, Italy
4
Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padua, Italy
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Materials Science Beamline, Elettra Sincrotrone Trieste SCpA, Strada Statale 14, km 163.5, 34149 Basovizza-Trieste, Italy
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Department for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics, 409 Atomistilor St., 077125 Magurele, Romania
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Physical Materials Science and Composite Materials Centre, National Research Tomsk Polytechnic University, Lenin Avenue 43, 634050 Tomsk, Russia
8
Surface Analysis Laboratory, INFN University Roma Tre, via della Vasca Navale 84, 00146 Rome, Italy
*
Authors to whom correspondence should be addressed.
Present address: FZU-Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, 18221 Prague, Czech Republic.
Nanomaterials 2020, 10(6), 1151; https://doi.org/10.3390/nano10061151
Received: 17 May 2020 / Revised: 7 June 2020 / Accepted: 9 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Advanced Biocompatible Nanomaterials)
Hydroxyapatite (HAP) coatings can improve the biocompatibility and bioactivity of titanium alloys, such as Ti6Al4V, commonly used as material for orthopedic prostheses. In this framework, we have studied the surface of HAP coatings enriched with Mg and either Si or Ti deposited by RF magnetron sputtering on Ti6Al4V. HAP coatings have been furtherly functionalized by adsorption of a self-assembling peptide (SAP) on the HAP surface, with the aim of increasing the material bioactivity. The selected SAP (peptide sequence AbuEAbuEAbuKAbuKAbuEAbuEAbuKAbuK) is a self-complementary oligopeptide able to generate extended ordered structures by self-assembling in watery solutions. Samples were prepared by incubation of the HAP coatings in SAP solutions and subsequently analyzed by X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared (FTIR) and Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopies, in order to determine the amount of adsorbed peptide, the peptide stability and the structure of the peptide overlayer on the HAP coatings as a function of the HAP substrate and of the pH of the mother SAP solution. Experimental data yielded evidence of SAP adsorption on the HAP surface, and peptide overlayers showed ordered structure and molecular orientation. The thickness of the SAP overlayer depends on the composition of the HAP coating. View Full-Text
Keywords: hydroxyapatite; self-assembling peptides; magnetron sputtering; Mg; Si and Ti dopants; XPS; NEXAFS; FTIR hydroxyapatite; self-assembling peptides; magnetron sputtering; Mg; Si and Ti dopants; XPS; NEXAFS; FTIR
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MDPI and ACS Style

Secchi, V.; Franchi, S.; Dettin, M.; Zamuner, A.; Beranová, K.; Vladescu, A.; Battocchio, C.; Graziani, V.; Tortora, L.; Iucci, G. Hydroxyapatite Surfaces Functionalized with a Self-Assembling Peptide: XPS, RAIRS and NEXAFS Study. Nanomaterials 2020, 10, 1151. https://doi.org/10.3390/nano10061151

AMA Style

Secchi V, Franchi S, Dettin M, Zamuner A, Beranová K, Vladescu A, Battocchio C, Graziani V, Tortora L, Iucci G. Hydroxyapatite Surfaces Functionalized with a Self-Assembling Peptide: XPS, RAIRS and NEXAFS Study. Nanomaterials. 2020; 10(6):1151. https://doi.org/10.3390/nano10061151

Chicago/Turabian Style

Secchi, Valeria, Stefano Franchi, Monica Dettin, Annj Zamuner, Klára Beranová, Alina Vladescu, Chiara Battocchio, Valerio Graziani, Luca Tortora, and Giovanna Iucci. 2020. "Hydroxyapatite Surfaces Functionalized with a Self-Assembling Peptide: XPS, RAIRS and NEXAFS Study" Nanomaterials 10, no. 6: 1151. https://doi.org/10.3390/nano10061151

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