Next Article in Journal
Carbon Nanotube Film Electrodes with Acrylic Additives: Blocking Electrochemical Charge Transfer Reactions
Next Article in Special Issue
Solid Plasmonic Substrates for Breast Cancer Detection by Means of SERS Analysis of Blood Plasma
Previous Article in Journal
The Effect of Heat Treatment on the Microstructure and Mechanical Properties of 2D Nanostructured Au/NiFe System
Previous Article in Special Issue
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
 
 
Article

Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

1
Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, Poland
2
Sydney Nano Institute, Faculty of Medicine and Health, Sydney School of Pharmacy, The University of Sydney, Pharmacy and Bank Building, Camperdown, NSW 2006, Australia
3
Institute of Nuclear Physics, Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342 Kraków, Poland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(6), 1076; https://doi.org/10.3390/nano10061076
Received: 15 April 2020 / Revised: 16 May 2020 / Accepted: 25 May 2020 / Published: 31 May 2020
(This article belongs to the Special Issue Application of Nanoscale Materials for Cancer Diagnostic and Therapy)
Superparamagnetic iron oxide nanoparticles (SPIONs) are promising drug delivery carriers and hyperthermia agents for the treatment of cancer. However, to ensure their safety in vivo, SPIONs must be modified in order to prevent unwanted iron release. Thus, SPIONs were coated with silica layers of different morphologies: non-porous (@SiO2), mesoporous (@mSiO2) or with a combination of non-porous and mesoporous layers (@SiO2@mSiO2) deposited via a sol–gel method. The presence of SiO2 drastically changed the surface properties of the nanoparticles. The zeta potential changed from 19.6 ± 0.8 mV for SPIONs to −26.1 ± 0.1 mV for [email protected]2. The Brunauer–Emmett–Teller (BET) surface area increased from 7.54 ± 0.02 m2/g for SPIONs to 101.3 ± 2.8 m2/g for [email protected]2. All types of coatings significantly decreased iron release (at least 10 fold as compared to unmodified SPIONs). SPIONs and [email protected]2 were tested in vitro in contact with human lung epithelial cells (A549 and BEAS-2B). Both nanoparticle types were cytocompatible, although some delay in proliferation was observed for BEAS-2B cells as compared to A549 cells, which was correlated with increased cell velocity and nanoparticles uptake. View Full-Text
Keywords: lung cancer; nanoparticles; nanoformualtions; controlled drug release; drug delivery; superparamagnetic iron oxide nanoparticles (SPIONs); silica coating; iron release; nano-bio-characterization; Atomic Force Microscopy lung cancer; nanoparticles; nanoformualtions; controlled drug release; drug delivery; superparamagnetic iron oxide nanoparticles (SPIONs); silica coating; iron release; nano-bio-characterization; Atomic Force Microscopy
Show Figures

Graphical abstract

  • Supplementary File 1:

    ZIP-Document (ZIP, 90313 KiB)

  • Externally hosted supplementary file 1
    Doi: 10.5281/zenodo.3752516
    Link: https://zenodo.org/deposit/3752516
    Description: Video S1: Growth of A549 control cells, Video S2: Growth of A549 cells incubated with 10 µg/ml of SPION, Video S3: Growth of A549 cells incubated with 10 µg/ml of [email protected], Video S4: Growth of BEAS-2B control cells, Video S5: Growth of BEAS-2B cells incubated with 10 µg/ml of SPION, Video S6: Growth of BEAS-2B cells incubated with 10 µg/ml of [email protected]
MDPI and ACS Style

Reczyńska, K.; Marszałek, M.; Zarzycki, A.; Reczyński, W.; Kornaus, K.; Pamuła, E.; Chrzanowski, W. Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment. Nanomaterials 2020, 10, 1076. https://doi.org/10.3390/nano10061076

AMA Style

Reczyńska K, Marszałek M, Zarzycki A, Reczyński W, Kornaus K, Pamuła E, Chrzanowski W. Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment. Nanomaterials. 2020; 10(6):1076. https://doi.org/10.3390/nano10061076

Chicago/Turabian Style

Reczyńska, Katarzyna, Marta Marszałek, Arkadiusz Zarzycki, Witold Reczyński, Kamil Kornaus, Elżbieta Pamuła, and Wojciech Chrzanowski. 2020. "Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment" Nanomaterials 10, no. 6: 1076. https://doi.org/10.3390/nano10061076

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop