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Article

Zinc Oxide Nanoparticles Damage Tobacco BY-2 Cells by Oxidative Stress Followed by Processes of Autophagy and Programmed Cell Death

1
Department of Pharmacognosy and Botany, The University of Veterinary Medicine and Pharmacy in Košice, Komenského 72, SK-041 81 Košice, Slovakia
2
Department of Mechanochemistry, Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 040 01 Košice, Slovakia
3
Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(6), 1066; https://doi.org/10.3390/nano10061066
Received: 16 April 2020 / Revised: 5 May 2020 / Accepted: 6 May 2020 / Published: 30 May 2020
Nanomaterials, including zinc oxide nanoparticles (ZnO NPs), have a great application potential in many fields, such as medicine, the textile industry, electronics, and cosmetics. Their impact on the environment must be carefully investigated and specified due to their wide range of application. However, the amount of data on possible negative effects of ZnO NPs on plants at the cellular level are still insufficient. Thus, we focused on the effect of ZnO NPs on tobacco BY-2 cells, i.e., a widely accepted plant cell model. Adverse effects of ZnO NPs on both growth and biochemical parameters were observed. In addition, reactive oxygen and nitrogen species visualizations confirmed that ZnO NPs may induce oxidative stress. All these changes were associated with the lipid peroxidation and changes in the plasma membrane integrity, which together with endoplasmatic reticulum and mitochondrial dysfunction led to autophagy and programmed cell death. The present study demonstrates that the phytotoxic effect of ZnO NPs on the BY-2 cells is very complex and needs further investigation. View Full-Text
Keywords: BY-2 cells; ZnO nanoparticles; oxidative stress; autophagy; programmed cell death; phytotoxicity BY-2 cells; ZnO nanoparticles; oxidative stress; autophagy; programmed cell death; phytotoxicity
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MDPI and ACS Style

Balážová, Ľ.; Baláž, M.; Babula, P. Zinc Oxide Nanoparticles Damage Tobacco BY-2 Cells by Oxidative Stress Followed by Processes of Autophagy and Programmed Cell Death. Nanomaterials 2020, 10, 1066. https://doi.org/10.3390/nano10061066

AMA Style

Balážová Ľ, Baláž M, Babula P. Zinc Oxide Nanoparticles Damage Tobacco BY-2 Cells by Oxidative Stress Followed by Processes of Autophagy and Programmed Cell Death. Nanomaterials. 2020; 10(6):1066. https://doi.org/10.3390/nano10061066

Chicago/Turabian Style

Balážová, Ľudmila, Matej Baláž, and Petr Babula. 2020. "Zinc Oxide Nanoparticles Damage Tobacco BY-2 Cells by Oxidative Stress Followed by Processes of Autophagy and Programmed Cell Death" Nanomaterials 10, no. 6: 1066. https://doi.org/10.3390/nano10061066

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