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Open AccessArticle

Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid

Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy
Department of Life and Environmental Sciences, Polytechnic University of Marche, I-60131 Ancona, Italy
Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, I-44121 Ferrara, Italy
Bavarian Polymer Institute (BPI) Keylab “Electron and Optical Microscopy”, University of Bayreuth, D-95440 Bayreuth, Germany
Institut Galien Paris Sud, CNRS, Université Paris-Saclay, 92296 Châtenay-Malabry, France
Diamond Light Source Ltd., Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0QG, UK
Plants for Human Health Institute, Animal Science Dept., NC Research Campus, NC State University, Kannapolis, NC 28081, USA
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(5), 961;
Received: 27 March 2020 / Revised: 24 April 2020 / Accepted: 26 April 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Advances in Nanotoxicology)
Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties. The object of this investigation was the development of a formulation for caffeic acid cutaneous administration. To this aim, caffeic acid has been loaded in solid lipid nanoparticles by hot homogenization and ultrasonication, obtaining aqueous dispersions with high drug encapsulation efficiency and 200 nm mean dimension, as assessed by photon correlation spectroscopy. With the aim to improve the consistence of the aqueous nanodispersions, different types of polymers have been considered. Particularly, poloxamer 407 and hyaluronic acid gels containing caffeic acid have been produced and characterized by X-ray and rheological analyses. A Franz cell study enabled to select poloxamer 407, being able to better control caffeic acid diffusion. Thus, a nanoparticulate gel has been produced by addition of poloxamer 407 to nanoparticle dispersions. Notably, caffeic acid diffusion from nanoparticulate gel was eight-fold slower with respect to the aqueous solution. In addition, the spreadability of nanoparticulate gel was suitable for cutaneous administration. Finally, the antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles. View Full-Text
Keywords: solid lipid nanoparticles; caffeic acid; poloxamer; small angle X-ray scattering; cigarette smoke solid lipid nanoparticles; caffeic acid; poloxamer; small angle X-ray scattering; cigarette smoke
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MDPI and ACS Style

Sguizzato, M.; Mariani, P.; Ferrara, F.; Drechsler, M.; Hallan, S.S.; Huang, N.; Simelière, F.; Khunti, N.; Cortesi, R.; Marchetti, N.; Valacchi, G.; Esposito, E. Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid. Nanomaterials 2020, 10, 961.

AMA Style

Sguizzato M, Mariani P, Ferrara F, Drechsler M, Hallan SS, Huang N, Simelière F, Khunti N, Cortesi R, Marchetti N, Valacchi G, Esposito E. Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid. Nanomaterials. 2020; 10(5):961.

Chicago/Turabian Style

Sguizzato, Maddalena; Mariani, Paolo; Ferrara, Francesca; Drechsler, Markus; Hallan, Supandeep S.; Huang, Nicolas; Simelière, Fanny; Khunti, Nikul; Cortesi, Rita; Marchetti, Nicola; Valacchi, Giuseppe; Esposito, Elisabetta. 2020. "Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid" Nanomaterials 10, no. 5: 961.

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