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Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

1
BIONAND—Centro Andaluz de Nanomedicina y Biotecnología (Junta de Andalucía, Universidad de Málaga), Parque Tecnológico de Andalucía, 29590 Málaga, Spain
2
Department of Physics, “Alexandru Ioan Cuza” University of Iasi, 700506 Iasi, Romania
3
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain
4
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 29590 Malaga, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(5), 907; https://doi.org/10.3390/nano10050907
Received: 26 March 2020 / Revised: 15 April 2020 / Accepted: 19 April 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Current Trends in Nanoscale Magnetism)
In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and CoFe2O4@MnFe2O4, which were developed as potential theranostic agents for magnetic hyperthermia and magnetic resonance imaging (MRI). These nanosystems have been thoroughly characterized by X-ray Diffraction (XRD), Transmission Electron Miscroscopy (TEM), Dark Field-TEM (DF-TEM), Vibrating Sample Magnetometry (VSM), and inductive heating, in order to elucidate their structure, morphology, and magnetic properties. The bi-magnetic CoFe2O4@ZnFe2O4 and CoFe2O4@MnFe2O4 nanoparticles (NPs) exhibited a core-shell structure with a mean average particle size of 11.2 ± 1.4 nm and 14.4 ± 2.4 nm, respectively. The CoFe2O4@MnFe2O4 NPs showed the highest specific absorption rate (SAR) values (210–320 W/g) upon exposure to an external magnetic field, along with the highest saturation magnetization (Ms). Therefore, they were selected for functionalization with the PEGylated ligand to make them stable in aqueous media. After the functionalization process, the NPs showed high magnetic relaxivity values and very low cytotoxicity, demonstrating that CoFe2O4@MnFe2O4 is a good candidate for in vivo applications. Finally, in vivo MRI experiments showed that PEGylated CoFe2O4@MnFe2O4 NPs produce high T2 contrast and exhibit very good stealth properties, leading to the efficient evasion of the mononuclear phagocyte system. Thus, these bi-magnetic core-shell NPs show great potential as theranostic agents for in vivo applications, combining magnetic hyperthermia capabilities with high MRI contrast. View Full-Text
Keywords: bi-magnetic nanoparticles; contrast agents; MRI; SAR; theranostics bi-magnetic nanoparticles; contrast agents; MRI; SAR; theranostics
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MDPI and ACS Style

Nica, V.; Caro, C.; Páez-Muñoz, J.M.; Leal, M.P.; Garcia-Martin, M.L. Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics. Nanomaterials 2020, 10, 907. https://doi.org/10.3390/nano10050907

AMA Style

Nica V, Caro C, Páez-Muñoz JM, Leal MP, Garcia-Martin ML. Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics. Nanomaterials. 2020; 10(5):907. https://doi.org/10.3390/nano10050907

Chicago/Turabian Style

Nica, Valentin, Carlos Caro, Jose M. Páez-Muñoz, Manuel P. Leal, and Maria L. Garcia-Martin 2020. "Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics" Nanomaterials 10, no. 5: 907. https://doi.org/10.3390/nano10050907

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