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Open AccessArticle

Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow

1
Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta Street, 30-059 Krakow, Poland
2
Department of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
3
Department of Histology, Jagiellonian University Medical College, 7a Kopernika Street, 31-034 Krakow, Poland
4
Department of Medicine, Jagiellonian University Medical College, 8 Skawinska Street, 31-066 Krakow, Poland
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(5), 859; https://doi.org/10.3390/nano10050859
Received: 28 February 2020 / Revised: 15 April 2020 / Accepted: 27 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Characterization of Nanomaterials)
Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements. View Full-Text
Keywords: polyelectrolyte multilayer films; blood-material interaction; natural heart valve; surface functionalization polyelectrolyte multilayer films; blood-material interaction; natural heart valve; surface functionalization
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MDPI and ACS Style

Imbir, G.; Mzyk, A.; Trembecka-Wójciga, K.; Jasek-Gajda, E.; Plutecka, H.; Schirhagl, R.; Major, R. Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow. Nanomaterials 2020, 10, 859. https://doi.org/10.3390/nano10050859

AMA Style

Imbir G, Mzyk A, Trembecka-Wójciga K, Jasek-Gajda E, Plutecka H, Schirhagl R, Major R. Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow. Nanomaterials. 2020; 10(5):859. https://doi.org/10.3390/nano10050859

Chicago/Turabian Style

Imbir, Gabriela; Mzyk, Aldona; Trembecka-Wójciga, Klaudia; Jasek-Gajda, Ewa; Plutecka, Hanna; Schirhagl, Romana; Major, Roman. 2020. "Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow" Nanomaterials 10, no. 5: 859. https://doi.org/10.3390/nano10050859

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