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Open AccessArticle

Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy

1
Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800008 Galati, Romania
2
Romanian National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, 060031 Bucharest, Romania
3
Laboratory of Biomaterials and Regenerative Medicine for Advanced Therapies, Indian Council of Medical Research-Regional Medical Research Center, Bhubaneswar-751 023, Odisha, India
4
Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy “Gr.T.Popa”, 700115 Iasi, Romania
5
Department of Chemistry, Physics and Environment, The European Centre of Excellence for the Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800008 Galati, Romania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(4), 698; https://doi.org/10.3390/nano10040698
Received: 15 March 2020 / Revised: 1 April 2020 / Accepted: 3 April 2020 / Published: 7 April 2020
(This article belongs to the Section Biology and Medicines)
Angiogenesis is a physiological process involving the growth of new blood vessels, which provides oxygen and required nutrients for the development of various pathological conditions. In a tumor microenvironment, this process upregulates the growth and proliferation of tumor cells, thus any stage of angiogenesis can be a potential target for cancer therapies. In the present study, chitosan and his derivatives have been used to design novel polymer-based nanoparticles. The therapeutic potential of these newly designed nanoparticles has been evaluated. The antioxidant and MTT assays were performed to know the antioxidant properties and their biocompatibility. The in vivo antiangiogenic properties of the nanoparticles were evaluated by using a chick Chorioallantoic Membrane (CAM) model. The obtained results demonstrate that chitosan derivatives-based nanostructures strongly enhance the therapeutic effect compared to chitosan alone, which also correlates with antitumor activity, demonstrated by the in vitro MTT assay on human epithelial cervical Hep-2 tumor cells. This study opens up new direction for the use of the chitosan derivatives-based nanoparticles for designing of antiangiogenic nanostructured materials, for future cancer therapy. View Full-Text
Keywords: angiogenesis; nanoparticles; chitosan derivatives; chorioallantoic membrane; cancer therapy; antioxidant action angiogenesis; nanoparticles; chitosan derivatives; chorioallantoic membrane; cancer therapy; antioxidant action
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MDPI and ACS Style

Dragostin, O.-M.; Tatia, R.; Samal, S.K.; Oancea, A.; Zamfir, A.S.; Dragostin, I.; Lisă, E.-L.; Apetrei, C.; Zamfir, C.L. Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy. Nanomaterials 2020, 10, 698.

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