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Open AccessArticle

6-Aza-2-Thio-Thymine Stabilized Gold Nanoclusters as Photoluminescent Probe for Protein Detection

Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China
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Nanomaterials 2020, 10(2), 281; https://doi.org/10.3390/nano10020281
Received: 31 December 2019 / Revised: 27 January 2020 / Accepted: 4 February 2020 / Published: 7 February 2020
This study puts forward an efficient method for protein detection in virtue of the tremendous fluorescence enhancement property of 6-aza-2-thio-thymine protected gold nanoclusters (ATT-AuNCs). In-depth studies of the protein-induced photoluminescence enhancement mechanism illustrate the mechanism of the interaction between ATT-AuNCs and protein. This new-established probe enables feasible and sensitive quantification of the concentrations of total protein in real samples, such as human serum, human plasma, milk, and cell extracts. The results of this proposed method are in good agreement with those determined by the classical bicinchoninic acid method (BCA method). View Full-Text
Keywords: gold nanocluster; 6-aza-2-thio-thymine; protein; fluorescence gold nanocluster; 6-aza-2-thio-thymine; protein; fluorescence
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Deng, H.-H.; Shi, X.-Q.; Balasubramanian, P.; Huang, K.-Y.; Xu, Y.-Y.; Huang, Z.-N.; Peng, H.-P.; Chen, W. 6-Aza-2-Thio-Thymine Stabilized Gold Nanoclusters as Photoluminescent Probe for Protein Detection. Nanomaterials 2020, 10, 281.

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