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Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

by Kaoru Aoki 1 and Naoto Saito 2,*
Physical Therapy Division, School of Health Sciences, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 264;
Received: 14 January 2020 / Accepted: 31 January 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Toxicology of Carbon Nanomaterials)
With the development of nanotechnology in recent years, there have been concerns about the health effects of nanoparticles. Carbon nanotubes (CNTs) are fibrous nanoparticles with a micro-sized length and nano-sized diameter, which exhibit excellent physical properties and are widely studied for their potential application in medicine. However, asbestos has been historically shown to cause pleural malignant mesothelioma and lung cancer by inhalation exposure. Because carbon nanotubes are also fibrous nanotubes, some have raised concerns about its possible carcinogenicity. We have reported that there is no clear evidence of carcinogenicity by local and intravenous administration of multi-walled CNTs to cancer mice models. We firmly believe that CNTs can be a safe, new, and high-performance biomaterials by controlling its type, site of administration, and dosage. View Full-Text
Keywords: carbon nanotubes; biocompatibility; carcinogenicity carbon nanotubes; biocompatibility; carcinogenicity
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Aoki, K.; Saito, N. Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials. Nanomaterials 2020, 10, 264.

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